Nilotinib Hydrochloride Dihydrate CAS 923289-71-8
| CAS No. | 923289-71-8 |
| Molecular Formula | C28H22F3N7O |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Nilotinib Hydrochloride Dihydrate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Nilotinib Hydrochloride Dihydrate (CAS 923289-71-8), molecular formula C28H22F3N7OHClH2O and molecular weight 584.00 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, Nilotinib Hydrochloride Dihydrate (C28H22F3N7OHClH2O) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 18.0, corresponding to approximately 18 ring(s) or double-bond equivalent(s). With a molecular weight of 584.00 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C28H22F3N7O HCl 2*H2O |
| Molecular Weight | 584.00 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 18.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 7 |
Related Nilotinib Standards
- Nilotinib Impurity N1 Nitrate salt (CAS 1025716-99-7)
- Nilotinib Genotoxic Impurity 2 (CAS 1157857-29-8)
- Nilotinib-d3 (CAS 1215678-43-5)
- Nilotinib N-Oxide (CAS 1246817-85-5)
- Nilotinib-d6 (CAS 1268356-17-7)
- Nilotinib Impurity A (CAS 1345336-53-9)
- Nilotinib Impurity 47 (CAS 1807606-80-9)
- Nilotinib Impurity 46 (CAS 1807607-72-2)
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