Nilotinib Impurity 47 CAS 1807606-80-9
| CAS No. | 1807606-80-9 |
| Molecular Formula | C28H22F3N7O2 |
| Molecular Weight | 545.52 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO supplies Nilotinib Impurity 47 (CAS 1807606-80-9), a pharmacopoeial impurity reference standard (molecular formula C28H22F3N7O2, MW 545.52 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Nilotinib Impurity 47 (C28H22F3N7O2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
CATO manufactures Nilotinib Impurity 47 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C28H22F3N7O2 |
| Molecular Weight | 545.52 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 20.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 7 |
Related Nilotinib Standards
- Nilotinib N-Oxide (CAS 1246817-85-5)
- Nilotinib N-Oxide (Imidazole N-Oxide) (CAS 2139382-75-3)
- Nilotinib Impurity 52 (CAS CATO-C4X-125652)
- Nilotinib Impurity 53 (CAS CATO-C4X-125653)
- Nilotinib Impurity 11 (CAS CATO-C4X-125611)
- Nilotinib Hydrochloride Monohydrate EP Impurity F (CAS 2119583-24-1)
- Nilotinib Impurity 43 (CAS CATO-C4X-125643)
- Nilotinib-d6 (CAS 1268356-17-7)
Recommended Standards
- 2-Nitrophenyl β-D-galactopyranoside-6-phosphate cyclohexylammonium salt (CAS 25405-62-3)
- N-[3-[[2-[[4-[[1-(2-Fluoroethyl)-3-azetidinyl]amino]-2-methoxyphenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]-2-propenamide (CAS 1375465-09-0)
- Elagolix Impurity 88 (CAS CATO-C4X-206888)
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- Edaravone Impurity 23 (CAS 29214-62-8)
- Milbemycin Impurity 10 (CAS CATO-C4X-169810)
- Cefadroxil Impurity 25 (CAS CATO-C4X-122425)
- N-[2-(1-aminoethyl)phenyl]methanesulfonamide hydrochloride (CAS 1170639-76-5)
- N,N'-(1,3-Phenylene)bis(2,3-dihydroxybenzamide) (CAS 368449-04-1)
- 2-chloro-N-(3,3-diphenylpropyl)acetamide (CAS 137075-21-9)
- 6-iodo-2,3-dimethyl-2H-indazole (CAS 1234616-58-0)
- Methyl 6H-furo[2,3-b]pyrrole-5-carboxylate (CAS 201019-27-4)
- Tamsulosin Impurity 74 (CAS CATO-C4X-118774)
- Biotinyl-Neuropeptide Y (human, rat) trifluoroacetate salt (CAS 213779-13-6)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com