Nilotinib N-Oxide CAS 1246817-85-5
| CAS No. | 1246817-85-5 |
| Molecular Formula | C28H22F3N7O2 |
| Molecular Weight | 545.52 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Nilotinib N-Oxide (C28H22F3N7O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 20.0, corresponding to approximately 20 ring(s) or double-bond equivalent(s). With a molecular weight of 545.52 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
CATO supplies Nilotinib N-Oxide (CAS 1246817-85-5), a certified reference material (molecular formula C28H22F3N7O2, MW 545.52 g/mol) for analytical method development and quality control.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), Nilotinib N-Oxide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C28H22F3N7O2 |
| Molecular Weight | 545.52 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 20.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 7 |
Related Nilotinib Standards
- Nilotinib N-Oxide (Imidazole N-Oxide) (CAS 2139382-75-3)
- Nilotinib Impurity 47 (CAS 1807606-80-9)
- Nilotinib Impurity 52 (CAS CATO-C4X-125652)
- Nilotinib Impurity 53 (CAS CATO-C4X-125653)
- Nilotinib Impurity 11 (CAS CATO-C4X-125611)
- Nilotinib Hydrochloride Monohydrate EP Impurity F (CAS 2119583-24-1)
- Nilotinib Impurity 43 (CAS CATO-C4X-125643)
- Nilotinib-d6 (CAS 1268356-17-7)
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