Nilotinib Impurity A CAS 1345336-53-9
| CAS No. | 1345336-53-9 |
| Molecular Formula | C20H19F3N6O |
| Molecular Weight | 416.40 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Nilotinib Impurity A (CAS 1345336-53-9), molecular formula C20H19F3N6O and molecular weight 416.40 g/mol, is a CATO reference standard with documented purity and traceability.
Based on its molecular formula C20H19F3N6O, Nilotinib Impurity A contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 416.40 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H19F3N6O |
| Molecular Weight | 416.40 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 6 |
Related Nilotinib Standards
- Nilotinib Genotoxic Impurity 2 (CAS 1157857-29-8)
- Nilotinib Impurity 44 (CAS CATO-C4X-125644)
- Nilotinib Impurity 19 (CAS 915711-42-1)
- Nilotinib Impurity 13 (CAS CATO-C4X-125613)
- Nilotinib Iodo Impurity (CAS 926922-18-1)
- Nilotinib Impurity 28 (CAS 641569-97-3)
- Nilotinib Impurity 45 (CAS CATO-C4X-125645)
- Nilotinib Hydrochloride Monohydrate EP Impurity G (CAS 917392-54-2)
Recommended Standards
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- Fluvoxamine Impurity 30 (CAS CATO-C4X-195130)
- 1-(1,4-Dioxaspiro[4.5]decan-8-yl)vinyl diphenyl phosphate (CAS 1936474-14-4)
- 6-Ethynyl-1H-indazole-3-carboxylic acid (CAS 2772514-99-3)
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- [1-(6-chloropyrimidin-4-yl)piperidin-2-yl]methanol (CAS 1247580-97-7)
- H-Trp-OBzl ยท HCl (CAS 35858-81-2)
- 3-(3-Bromophenyl)-5-hydroxyisoxazole (CAS 1188158-52-2)
- (R)-N-(4-bromobenzylidene)-2-methylpropane-2-sulfinamide (CAS 1206640-93-8)
- Papaverine Impurity 2 (CAS 18813-60-0)
- 1-Ethyl-4-(phenylsulfonyl)-1,2,3,4-tetrahydroquinoxaline (CAS 7151-18-0)
- 2-[4-(1H-Imidazol-1-yl)phenyl]-2-{[3-methyl-4-(propan-2-yl)phenyl]amino}acetonitrile (CAS 866157-83-7)
- Tirzepatide Impurity 12 (CAS CATO-C4X-324012)
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