Trimethoprim Impurity 1 CAS 93885-69-9
| CAS No. | 93885-69-9 |
| Molecular Formula | C14H16N2O5 |
| Molecular Weight | 292.29 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Trimethoprim Impurity 1 (C14H16N2O5) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Trimethoprim Impurity 1 (CAS 93885-69-9) is a high-purity analytical reference standard with the molecular formula C14H16N2O5 and a molecular weight of 292.29 g/mol.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H16N2O5 |
| Molecular Weight | 292.29 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1983 |
| Nitrogen Atoms | 2 |
Related Trimethoprim Standards
- Trimethoprim EP Impurity D (CAS 92440-76-1)
- Trimethoprim EP Impurity E (CAS 60729-91-1)
- Trimethoprim-13C3 (CAS 1189970-95-3)
- Trimethoprim-d3 (CAS 1189923-38-3)
- Trimethoprim (CAS 738-70-5)
- Trimethoprim-d9 (CAS 1189460-62-5)
- Trimethoprim EP Impurity B (CAS 30806-86-1)
- Trimethoprim EP Impurity A (CAS 213745-86-9)
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