Busulfan Impurity 6 CAS 928-51-8

Purity >85%In StockPharmacopoeial Impurity Standards
CAS No.928-51-8
Molecular FormulaC4H9ClO
Molecular Weight108.57 g/mol
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Busulfan Impurity 6 CAS 928-51-8 chemical structure

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Busulfan Impurity 6.

As a process- or degradation-related impurity, Busulfan Impurity 6 (CAS 928-51-8, C4H9ClO) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.

Owing to a hydroxyl group, an ether linkage, chlorine substitution, Busulfan Impurity 6 is typically white to off-white liquid. Its solid-state physicochemical attributes — including a molecular weight of 108.57 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.

Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.

As a certified reference material (CRM), Busulfan Impurity 6 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

Molecular FormulaC4H9ClO
Molecular Weight108.57 g/mol
Purity>85%
StorageStore at 2-8°C, keep tightly closed to prevent evaporation
Solubility (reference)Soluble in methanol, acetonitrile, DMSO, water (slightly soluble)
StabilityStable under recommended storage conditions
Degree of Unsaturation (DBE)0.0
CAS Registry Year (est.)1957
Halogen ContentCl-containing

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