Ranolazine Impurity 6 CAS 93-14-1
| CAS No. | 93-14-1 |
| Molecular Formula | C10H14O4 |
| Molecular Weight | 198.22 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Ranolazine Impurity 6 is closely related to a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Ranolazine Impurity 6 (CAS 93-14-1, C10H14O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Ranolazine Impurity 6 (C10H14O4) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Ranolazine Impurity 6 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H14O4 |
| Molecular Weight | 198.22 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
Related Ranolazine Standards
- Ranolazine Chloridrine (CAS 141987-47-5)
- Ranolazine Impurity 7 (CAS 5294-61-1)
- Ranolazine Impurity 2 (CAS 162712-35-8)
- Ranolazine Impurity 13 (CAS CATO-C4X-102613)
- Ranolazine Impurity 9 (CAS CATO-C4X-10269)
- Ranolazine Impurity 21 (CAS 172430-46-5)
- Ranolazine Impurity 20 DiHCl (CAS 1185293-30-4)
- Ranolazine-D8 Dihydrochloride (CAS 1219802-60-4)
Recommended Standards
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- Istradefylline Impurity 11 (CAS 52998-22-8)
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- Edoxaban impurity 129 (CAS CATO-C4X-1063129)
- Acalabrutinib Impurity 2 (CAS CATO-C4X-30552)
- Vincristine Impurity N1 (CAS 947527-73-3)
- Bilastine Impurity 22 (CAS CATO-C4X-225322)
- (R)-N-cyclopentylidene-2-methylpropane-2-sulfinamide (CAS 891782-29-9)
- 5-Nitro-2-(pyrrolidin-1-yl)aniline (CAS 5367-55-5)
- 2-(7-Methyl-1,7-diazaspiro[4.4]nonan-1-yl)-1,3,4-oxadiazole (CAS 646056-41-9)
- n-(2-Cyclohexylethyl)tetrazolo[1,5-b]pyridazin-6-amine (CAS 1197722-88-5)
- 2-(Ethylamino)isonicotinic acid (CAS 86649-58-3)
- n-Isopropyl-5,6-dimethylthieno[2,3-d]pyrimidin-4-amine (CAS 63895-01-2)
- Epidermal Growth Factor Receptor Peptide (985-996) (CAS 96249-43-3)
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