Drospirenone EP Impurity G CAS 932388-90-4
| CAS No. | 932388-90-4 |
| Molecular Formula | C24H31ClO3 |
| Molecular Weight | 402.95 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Drospirenone EP Impurity G.
Drospirenone EP Impurity G (CAS 932388-90-4) is a certified pharmaceutical impurity reference standard with the molecular formula C24H31ClO3 and a molecular weight of 402.95 g/mol.
The molecular framework of Drospirenone EP Impurity G (C24H31ClO3) is characterized by a steroid core, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Drospirenone EP Impurity G meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C24H31ClO3 |
| Molecular Weight | 402.95 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
Related Drospirenone Standards
- Drospirenone EP Impurity H (CAS 932388-89-1)
- Drospirenone Impurity 12 (CAS 82543-18-8)
- Drospirenone 3,5,5-Triol (CAS 1079392-41-8)
- Drospirenone Impurity 13(Mixture of Diastereomers) (CAS CATO-C4X-162413)
- Drospirenone 5,5-Diol (CAS 863329-70-8)
- Drospirenone Impurity 17 (CAS 82543-17-7)
- Drospirenone AcidDISCONTINUED, offer stable alternates (CAS 776251-13-9)
- Drospirenone EP Impurity B (CAS CATO-C4X-16242)
Recommended Standards
- 2-[(4-Chlorophenyl)sulfanyl]-4-(4-cyclohexylphenyl)-4-oxobutanoic acid (CAS 329703-21-1)
- 4-(4-(2-Chlorophenyl)-2-phenyloxazol-5-yl)-N,N-diethylaniline (CAS 55766-52-4)
- Methyl 4-amino-3,5-diiodobenzoate (CAS 131755-87-8)
- Cyproterone Acetate EP Impurity I (CAS 13698-49-2)
- Venetoclax Impurity 81 (CAS CATO-C4X-249581)
- Scopolamine impurity 23 (CAS CATO-C4X-195823)
- Alvimopan impurity 11 (CAS CATO-C4X-114511)
- 2-(1-(2-Methylpiperazin-1-yl)ethyl)pyrazine hydrochloride (CAS 1289386-79-3)
- 2-Chloro-1-(2,8-dimethyl-1,2,3,4,4a,9b-hexahydro-5H-pyrido[4,3-b]indol-5-yl)ethan-1-one hydrochloride (CAS 1208463-10-8)
- 1-(2,2-Difluoroethoxy)-2-methoxy-4-nitrobenzene (CAS 1245773-14-1)
- 4-Bromo-2-methoxybenzotrifluoride (CAS 944805-63-4)
- 3-Carboethoxy-3-(2,3-dimethylphenyl)propiophenone (CAS 898769-23-8)
- 4,4'-Sulfonyldipyridine (CAS 101728-06-7)
- Semaglutide Impurity 142 (CAS CATO-C4X-2226142)
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