Nicotinic Acid EP Impurity I CAS 940-06-7
| CAS No. | 940-06-7 |
| Molecular Formula | C5H3N3O4 |
| Molecular Weight | 169.10 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Nicotinic Acid EP Impurity I (C5H3N3O4) is characterized by a carbohydrate-derived structure, an amide group. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Nicotinic Acid EP Impurity I (CAS 940-06-7) is a certified pharmaceutical impurity reference standard with the molecular formula C5H3N3O4 and a molecular weight of 169.10 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C5H3N3O4 |
| Molecular Weight | 169.10 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 3 |
Related Nicotinic Standards
- Nicotinic Acid-2-Methylmercapto (CAS 74470-23-8)
- 28125-84-0 Nicotinic acid, 1,2,5,6-tetrahydro-1-methyl-, ethyl ester 5-22-01-00323 (Beilstein Handbook Reference) BRN 0125290 Ethyl 1-methyl-1,2,5,6-tetrahydronicotinate Arecaidine-ethyl ester Arecaidine ethyl ester (CAS 28125-84-0)
- Nicotinic Acid EP Impurity F (CAS 2047-49-6)
- Nicotinic Acid EP Impurity D (CAS 100-26-5)
- Nicotinic Acid Methyl Ester 5-N-Methylnitrone (CAS 1159977-53-3)
- Nicotinic Acid N-Oxide (CAS 2398-81-4)
- Nicotinic Acid-6-Hydroxy (CAS 5006-66-6)
- Nicotinic Acid EP Impurity A (CAS 3222-47-7)
Recommended Standards
- 3-methyl-5-(trifluoromethyl)-4,5-dihydroisoxazol-5-ol (CAS 51479-84-6)
- 3-Fluoro-5-nitrobenzaldehyde (CAS 108159-96-2)
- 3,4,5-trifluoro-1H-pyrrole-2-carboxylic acid (CAS 2448324-86-3)
- 6-Fluoro-4-formylpicolinic acid (CAS 1288995-49-2)
- Icaritin Impurity 8 (CAS 13620-31-0)
- Ethacridine Lactate EP Impurity C (CAS CATO-C4X-26093)
- Orforglipron Impurity 53 (CAS CATO-C4X-323453)
- 3-Bromo-4-chloro-6-fluoroquinoline (CAS 1204810-93-4)
- Olaparib Impurity 104 (CAS 545348-09-2)
- 2,2'-Oxybis(5,5-dimethyl-1,3,2-dioxaborinane) (CAS 55089-03-7)
- [3-(thiophen-3-yl)-1,2,4-oxadiazol-5-yl]methanamine (CAS 1156232-02-8)
- N-(1-Cyanopropyl)-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide (CAS 1803603-64-6)
- 3-Amino-6-cyclopropylpyridazine (CAS 1159814-07-9)
- Prolactin-Releasing Peptide (12-31) (human) (CAS 235433-36-0)
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