Olaparib Impurity 104 CAS 545348-09-2
| CAS No. | 545348-09-2 |
| Molecular Formula | C9H16N2O |
| Molecular Weight | 168.24 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Olaparib Impurity 104.
As a process- or degradation-related impurity, Olaparib Impurity 104 (CAS 545348-09-2, C9H16N2O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Olaparib Impurity 104 (C9H16N2O) is characterized by an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Olaparib Impurity 104 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H16N2O |
| Molecular Weight | 168.24 g/mol |
| Appearance | White to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1984 |
| Nitrogen Atoms | 2 |
Related Olaparib Standards
- Olaparib Impurity 33 (CAS 550363-85-4)
- Olaparib Impurity 64 (CAS 155295-47-9)
- Olaparib Impurity 73 (CAS 164149-28-4)
- Olaparib Impurity 60 (CAS CATO-C4X-113560)
- Olaparib Impurity 80 (CAS 4122-56-9)
- Olaparib Impurity 81 (CAS 4122-57-0)
- Olaparib impurity 144 (CAS CATO-C4X-1135144)
- Olaparib Impurity 77 (CAS 1937362-45-2)
Recommended Standards
- Pseudopelletierine oxime (CAS 6164-67-6)
- Lemborexant impurity 2 (CAS 1547757-91-4)
- 99158-61-9 [1,3]Thiazolo[4,5-b]pyridine-2(3H)-thione DTXSID50611367 (CAS 99158-61-9)
- Aceclidine Impurity 2 (CAS 6238-15-9)
- Minocycline impurity 55 (CAS CATO-C4X-169955)
- Clopidogrel Impurity 6 (CAS 1357474-92-0)
- Isavuconazole Impurity 11 (CAS CATO-C4X-123611)
- Dobutamine Impurity 16 (CAS CATO-C4X-129816)
- 2-Phenylimidazo[1,2-a]pyridin-6-ylboronic acid (CAS 1187822-25-8)
- (5-Chloropyridin-3-yl)amine 22353-34-0 3-Amino-5-chloropyridine 5-Chloro-3-pyridinamine (CAS 22353-34-0)
- 4-Isocyanato-1H-indole (CAS 581812-74-0)
- (1,3-Diphenyl-1h-pyrazol-4-yl)methanol (CAS 40278-32-8)
- 1-(Dimethylsulfamoyl)pyrrole-2-boronic acid (CAS 2377610-03-0)
- Tirzepatide Impurity 21 X TFA Salt (CAS CATO-C4X-324021)
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