Pomalidomide Impurity 46 CAS 944709-53-9
| CAS No. | 944709-53-9 |
| Molecular Formula | C5HCl2N3O |
| Molecular Weight | 189.99 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Pomalidomide Impurity 46.
CATO supplies Pomalidomide Impurity 46 (CAS 944709-53-9), a pharmacopoeial impurity reference standard (molecular formula C5HCl2N3O, MW 189.99 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Pomalidomide Impurity 46 (C5HCl2N3O) contains an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 6.0, corresponding to approximately 6 ring(s) or double-bond equivalent(s). With a molecular weight of 189.99 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Pomalidomide Impurity 46 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C5HCl2N3O |
| Molecular Weight | 189.99 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Pomalidomide Standards
- Pomalidomide Impurity 36 (CAS 641-70-3)
- Pomalidomide Impurity 37 (CAS 5466-84-2)
- Pomalidomide Impurity 62 (CAS CATO-C4X-135462)
- Pomalidomide Impurity 7 (CAS 5434-21-9)
- Pomalidomide Impurity 31 (CAS 610-27-5)
- Pomalidomide Impurity 8 (CAS 603-11-2)
- Pomalidomide Impurity 47 (CAS 885278-16-0)
- Pomalidomide Impurity 3 (CAS 328-48-3)
Recommended Standards
- 5-Bromopyridine-2,3-diol (CAS 34206-49-0)
- 3,5-Dichloro-4-fluorobenzonitrile (CAS 103879-31-8)
- 5-Bromofuran-2-carboxamide (CAS 6134-61-8)
- 6-Bromo-1,2,4-triazine-3,5-diamine (CAS 104405-59-6)
- Indapamide Impurity 33 (CAS 22160-13-0)
- Semaglutide Impurity 162 (x TFA Salt) (CAS CATO-C4X-2226162)
- Finasteride Impurity 20 (CAS 190006-01-0)
- Azilsartan Impurity 107 (CAS CATO-C4X-1096107)
- 1,7-Difluoroheptane (CAS 693-46-9)
- 3-(4-Ethylbenzoyl)-4-methylpyridine (CAS 1187168-18-8)
- Methisosildenafil Impurity 2 (CAS 1425504-78-4)
- 1-Benzyl-4-[3-(4-chlorobenzenesulfonyl)-4,6-dimethylpyridin-2-yl]piperazine (CAS 478245-23-7)
- (3-Bromo-2-isopropoxyphenyl)methanol (CAS 1250782-97-8)
- Biotinyl-CBP501 Affinity Peptide trifluoroacetate salt (CAS 2022956-39-2)
Why CATO?
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