Pomalidomide Impurity 36 CAS 641-70-3
| CAS No. | 641-70-3 |
| Molecular Formula | C8H3NO5 |
| Molecular Weight | 193.11 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Pomalidomide Impurity 36.
As a process- or degradation-related impurity, Pomalidomide Impurity 36 (CAS 641-70-3, C8H3NO5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C8H3NO5, Pomalidomide Impurity 36 contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 193.11 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H3NO5 |
| Molecular Weight | 193.11 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 1 |
Related Pomalidomide Standards
- Pomalidomide Impurity 37 (CAS 5466-84-2)
- Pomalidomide Impurity 46 (CAS 944709-53-9)
- Pomalidomide Impurity 62 (CAS CATO-C4X-135462)
- Pomalidomide Impurity 7 (CAS 5434-21-9)
- Pomalidomide Impurity 31 (CAS 610-27-5)
- Pomalidomide Impurity 8 (CAS 603-11-2)
- Pomalidomide Impurity 47 (CAS 885278-16-0)
- Pomalidomide Impurity 3 (CAS 328-48-3)
Recommended Standards
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- 3-((Difluoromethoxy)methyl)isoxazole-4-carboxylic acid (CAS 2735654-47-2)
- 1-Bromo-2,2-dimethylhexane (CAS 101419-70-9)
- 1-(1,1-Difluoro-2-hydroxyethyl)-1H-1,2,3-triazole-4-carboxylic acid (CAS 2137586-19-5)
- Rapamycin Impurity 14 (CAS CATO-C4X-174614)
- Lubiprostone Impurity 42 (CAS CATO-C4X-113642)
- Indobufen Impurity 67 (CAS CATO-C4X-179267)
- 2-(4-Fluorophenyl)-1,3-thiazolidine-4-carboxylic acid (CAS 69570-82-7)
- 2-Amino-3-(2,3-dihydrobenzo[b][1,4]dioxine-6-carbonyl)-5,6,7,8-tetrahydroindolizine-1-carbonitrile (CAS 924861-89-2)
- 2-(3,4-Dimethoxyphenyl)indane-2-carbonitrile (CAS 1160264-27-6)
- 4-(3,5-Dimethoxyphenyl)-5-((naphthalen-1-yloxy)methyl)-4H-1,2,4-triazole-3-thiol (CAS 917746-56-6)
- 3-Chloropropionitrile (CAS 542-76-7)
- 1-(2-BROMOPHENYL)-3-METHYLBUTAN-1-ONE (CAS 213382-03-7)
- Acetyl tetrapeptide-9(Dermican LS 9837) (CAS 928006-50-2)
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