Thioctic acid Impurity 28 CAS 947236-49-9
| CAS No. | 947236-49-9 |
| Molecular Formula | C10H19ClO3 |
| Molecular Weight | 222.71 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Thioctic acid Impurity 28 is closely related to a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Thioctic acid Impurity 28 (CAS 947236-49-9, C10H19ClO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Thioctic acid Impurity 28 (C10H19ClO3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Thioctic acid Impurity 28 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C10H19ClO3 |
| Molecular Weight | 222.71 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 1.0 |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
Related Thioctic Standards
- Thioctic Acid Impurity 8 (CAS 1070-65-1)
- Thioctic acid Impurity 74 (CAS 852383-82-5)
- Thioctic acid Impurity 94 (CAS 50628-93-8)
- Thioctic acid Impurity 10 (CAS 188783-96-2)
- Thioctic acid Impurity 12 (CAS CATO-C4X-152612)
- Thioctic acid Impurity 2 (CAS 108015-78-7)
- Thioctic acid Impurity 20 (CAS 2114407-83-7)
- Thioctic acid Impurity 26 (CAS 2114407-76-8)
Recommended Standards
- Chlorpheniramine Impurity 16 (CAS 73775-50-5)
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- 1-p-Tolyl-cyclopentanecarbonyl chloride 1-p-tolylcyclopentanecarbonyl chloride 82278-33-9 (CAS 82278-33-9)
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- Progesterone Impurity 15 (CAS 604-20-6)
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Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com