Olopatadine Impurity 52 CAS 949141-21-3
| CAS No. | 949141-21-3 |
| Molecular Formula | C21H25NO4 |
| Molecular Weight | 355.43 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Olopatadine Impurity 52.
Olopatadine Impurity 52 (CAS 949141-21-3) is a certified pharmaceutical impurity reference standard with the molecular formula C21H25NO4 and a molecular weight of 355.43 g/mol.
Structurally, Olopatadine Impurity 52 (C21H25NO4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 10.0, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 355.43 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Olopatadine Impurity 52 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H25NO4 |
| Molecular Weight | 355.43 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Nitrogen Atoms | 1 |
Related Olopatadine Standards
- Olopatadine-d3 N-Oxide (CAS 1246832-94-9)
- Olopatadine Impurity N1 (CAS 203188-31-2)
- Olopatadine USP Related Compound B (CAS 173174-07-7)
- Olopatadine Impurity 69 (CAS CATO-C4X-171869)
- Olopatadine Impurity 49 (CAS CATO-C4X-171849)
- Olopatadine Impurity 51 (CAS 113806-01-2)
- Olopatadine Impurity 73 (CAS CATO-C4X-171873)
- Olopatadine Amide (CAS 872041-02-6)
Recommended Standards
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- Pitavastatin Impurity 25 (CAS CATO-C4X-103725)
- Boceprevir Impurity 9 (CAS CATO-C4X-25259)
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- 3-Chloro-4-iodothiophene (CAS 2160743-90-6)
- 1-((4-(Tert-butyl)phenyl)sulfonyl)-4-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine (CAS 260368-22-7)
- 1-(1H-Benzo[d][1,2,3]triazol-1-yl)-2-(1H-indol-3-yl)ethanone (CAS 1080025-88-2)
- Tert-butyl 2-benzyl-2,6-diazaspiro[3.5]Nonane-6-carboxylate (CAS 1206969-43-8)
- 3-Oxo-7-(trifluoromethyl)-3,4-dihydroquinoxaline-2-carboxylic acid (CAS 219485-21-9)
- Semaglutide impurity 290 (CAS CATO-C4X-2226290)
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