Abemaciclib Impurity 138 CAS CATO-C4X-2937138
| CAS No. | CATO-C4X-2937138 |
| Molecular Formula | C27H30F2N8O |
| Molecular Weight | 520.58 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Abemaciclib Impurity 138 (C27H30F2N8O) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
CATO supplies Abemaciclib Impurity 138 (CAS CATO-C4X-2937138), a pharmacopoeial impurity reference standard (molecular formula C27H30F2N8O, MW 520.58 g/mol) used for the identification and quantification of trace impurities in APIs.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C27H30F2N8O |
| Molecular Weight | 520.58 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 8 |
Related Abemaciclib Standards
- Abemaciclib Impurity 137 (CAS CATO-C4X-2937137)
- Abemaciclib Impurity 59 (CAS CATO-C4X-293759)
- Abemaciclib Impurity 103 (CAS CATO-C4X-2937103)
- Abemaciclib Impurity 80 (CAS CATO-C4X-293780)
- Abemaciclib Impurity 81 (CAS CATO-C4X-293781)
- Abemaciclib Impurity 84 (CAS CATO-C4X-293784)
- Abemaciclib Impurity 134 (CAS CATO-C4X-2937134)
- Abemaciclib Impurity 17 (CAS CATO-C4X-293717)
Recommended Standards
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- Levothyroxine EP Impurity C (CAS 51-24-1)
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- 3-Methoxy-5-(p-tolyl)-1H-1,2,4-triazole (CAS 62036-08-2)
- Acetyl Hexapeptide-39 (CAS 1382088-38-1)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com