2-Chloro-5-fluoro-3-(trifluoromethyl)-benzaldehyde CAS 95445-69-5
| CAS No. | 95445-69-5 |
| Molecular Formula | C8H3ClF4O |
| Molecular Weight | 226.56 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
2-Chloro-5-fluoro-3-(trifluoromethyl)-benzaldehyde (CAS 95445-69-5), molecular formula C8H3ClF4O and molecular weight 226.56 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system, 2-Chloro-5-fluoro-3-(trifluoromethyl)-benzaldehyde is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 226.56 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), 2-Chloro-5-fluoro-3-(trifluoromethyl)-benzaldehyde meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H3ClF4O |
| Molecular Weight | 226.56 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1984 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
- 5-Chloro-2-fluoro-3-(trifluoromethyl)benzaldehyde (CAS 117752-05-3)
- 1-(2-Chloro-6-fluorophenyl)-2,2,2-trifluoroethan-1-one (CAS 1208077-59-1)
- 3-Chloro-2-fluoro-4-(trifluoromethyl)benzaldehyde (CAS 134099-21-1)
- 5-Chloro-4-fluoro-2-(trifluoromethyl)benzaldehyde (CAS 134099-23-3)
- 2-Chloro-4-fluoro-6-(trifluoromethyl)benzaldehyde (CAS 134099-27-7)
- 3-Chloro-4-fluoro-5-(trifluoromethyl)benzaldehyde (CAS 134099-29-9)
- 5-Chloro-2-fluoro-4-(trifluoromethyl)benzaldehyde (CAS 134099-32-4)
- 2-Chloro-1-(3,4-difluorophenyl)-2,2-difluoroethan-1-one (CAS 1352215-14-5)
Recommended Standards
- 2-Chloro-4-fluoro-2,2,2-trifluoroacetophenone (CAS 886370-93-0)
- 2-Fluoro-3-trifluoromethylbenzoyl Chloride (CAS 208173-19-7)
- 1-(5-Chloro-2-fluorophenyl)-2,2,2-trifluoroethanone (CAS 617706-16-8)
- 3-Chloro-2-fluoro-5-(trifluoromethyl)benzaldehyde (CAS 261763-02-4)
- N-(2-Hydroxyphenyl)-2,4-dimethylbenzenesulfonamide (CAS 1039984-24-1)
- 2-(3-Oxoisoindolin-1-yl)acetic acid (CAS 3849-22-7)
- 7-Chloroindole-3-carbaldehyde (CAS 1008-07-7)
- 3,5-Bis(trifluoromethyl)benzylboronic acid (CAS 1451393-52-4)
- 4-Chloro-1-(cyclopropylmethyl)-6-(trifluoromethyl)-1H-pyrazolo[3,4-d]pyrimidine (CAS 1443287-85-1)
- 2,2-Difluoro-1-(m-tolyl)ethan-1-one (CAS 50562-05-5)
- DL-Dithiothreitol (CAS 3483-12-3)
- 1-Hexylsodiumsulfonate (CAS 2207-98-9)
- (4-Fluorophenyl)(4-nitrophenyl)methanone (CAS 2195-47-3)
- Semaglutide impurity 76 (CAS CATO-C4X-222676)
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