3-(Difluoromethoxy)-4-methylphenylboronic acid CAS 958451-74-6
| CAS No. | 958451-74-6 |
| Molecular Formula | C8H9BF2O3 |
| Molecular Weight | 201.96 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies 3-(Difluoromethoxy)-4-methylphenylboronic acid (CAS 958451-74-6), a certified reference material (molecular formula C8H9BF2O3, MW 201.96 g/mol) for analytical method development and quality control.
Structurally, 3-(Difluoromethoxy)-4-methylphenylboronic acid (C8H9BF2O3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 3.5, corresponding to approximately 3 ring(s) or double-bond equivalent(s). With a molecular weight of 201.96 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H9BF2O3 |
| Molecular Weight | 201.96 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.5 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
Related Difluoromethoxy Standards
- (4-(Difluoromethoxy)-2-methylphenyl)boronic acid (CAS 514206-39-4)
- (4-(Difluoromethoxy)-3-methylphenyl)boronic acid (CAS 958451-72-4)
- [2-(Difluoromethoxy)-3-methylphenyl]boronic acid (CAS 958451-78-0)
- [2-(Difluoromethoxy)-5-methylphenyl]boronic acid (CAS 958451-75-7)
- 2-(Difluoromethoxy)-4-methoxybenzaldehyde (CAS 1247613-99-5)
- 3-(difluoromethoxy)-4-methylbenZoic acid (CAS 1249751-97-0)
- 4-(Difluoromethoxy)-3-methylbenzoic acid (CAS 1427373-23-6)
- 3-(Difluoromethoxy)-5-methylbenzoic acid (CAS 1427403-26-6)
Recommended Standards
- 2,6-Difluoro-3-ethoxyphenylboronic acid (CAS 849062-00-6)
- 3,4-Dichloro-2,5,6-trifluoropyridine (CAS 52026-99-0)
- 2,4-Difluoro-3-methoxy-5-methylphenylboronic acid (CAS 2096331-81-4)
- 3,5-Difluoro-4-methoxy-2-methylphenylboronic acid (CAS 2096338-65-5)
- 5-Bromo-2-butoxy-1-chloro-3-fluorobenzene (CAS 1881292-96-1)
- 1-(2-Benzoyl-4-chlorophenyl)-3,3-dimethylazetidin-2-one (CAS 303985-84-4)
- Eprinomectin B1b (CAS 133305-89-2)
- 1-(4-EThylphenyl)-1h-pyrrole (CAS 383137-78-8)
- 4,4,6,6-Tetramethyl-4,6-dihydro-1H-furo[3,4-c]pyrazole (CAS 92939-32-7)
- Gossypolone (CAS 4547-72-2)
- 2-(2,2-difluoroethoxy)pyridin-3-amine (CAS 1332761-15-5)
- 7-Bromo-3-chloro-6-fluoroquinoline (CAS 2354421-52-4)
- 9-(4-Methylphenyl)-2,4-bis(trifluoromethyl)-[1,2,4]triazolo[4,3-a]1,8-naphthyridine (CAS 338962-35-9)
- Semaglutide Impurity 186 (CAS CATO-C4X-2226186)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com