2-(Difluoromethoxy)-4-fluorophenylboronic acid CAS 958451-73-5
| CAS No. | 958451-73-5 |
| Molecular Formula | C7H6BF3O3 |
| Molecular Weight | 205.93 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies 2-(Difluoromethoxy)-4-fluorophenylboronic acid (CAS 958451-73-5), a certified reference material (molecular formula C7H6BF3O3, MW 205.93 g/mol) for analytical method development and quality control.
The molecular framework of 2-(Difluoromethoxy)-4-fluorophenylboronic acid (C7H6BF3O3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-(Difluoromethoxy)-4-fluorophenylboronic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H6BF3O3 |
| Molecular Weight | 205.93 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.5 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
Related Difluoromethoxy Standards
- (4-(Difluoromethoxy)-2-fluorophenyl)boronic acid (CAS 1004775-34-1)
- (2-(Difluoromethoxy)-5-fluorophenyl)boronic acid (CAS 958451-71-3)
- (3-(Difluoromethoxy)-5-fluorophenyl)boronic acid (CAS 2055539-69-8)
- 2-(Difluoromethoxy)-3-fluorophenylboronic acid (CAS 958451-76-8)
- 3-(Difluoromethoxy)-4-fluorophenylboronic acid (CAS 958451-70-2)
- 4-(Difluoromethoxy)-3-fluorophenylboronic Acid (CAS 958451-69-9)
- 2-(Difluoromethoxy)-5-fluorobenzoic acid (CAS 1017779-44-0)
- 4-(Difluoromethoxy)-2-fluorobenzoic acid (CAS 1017779-52-0)
Recommended Standards
- 2-Hydroxy-5-(trifluoromethyl)phenylboronic acid (CAS 779329-55-4)
- (6-Amino-2-(trifluoromethyl)pyridin-3-yl)boronic acid (CAS 2096338-90-6)
- 2-Hydroxy-6-trifluoromethylphenylboronic acid (CAS 2096333-79-6)
- (4-Hydroxy-2-(trifluoromethyl)phenyl)boronic acid (CAS 943918-05-6)
- 4-Chloro-3-(6-methylbenzo[d]oxazol-2-yl)aniline (CAS 293737-71-0)
- 2-Methyloxazolo[4,5-d]pyrimidine (CAS 129249-41-8)
- tert-butyl 5-formyl-1-methyl-1H-pyrazole-3-carboxylate (CAS 2059933-79-6)
- 7,8-Dihydro-[1,4]dioxino[2,3-g]quinazolin-4-amine (CAS 21560-93-0)
- 11-Azido-1-undecanol (CAS 122161-09-5)
- 2-Amino-2-(4-methoxyphenyl)acetonitrile hydrochloride (CAS 5537-50-8)
- Pyrrolo[1,2-c]pyrimidin-1(2H)-one (CAS 223432-96-0)
- 2-(2,5-Dimethylpiperidin-1-yl)ethan-1-amine (CAS 1493059-69-0)
- n-Methyl-2-phenylethane-1-sulfonamide (CAS 95339-74-5)
- Semaglutide impurity 34 (CAS CATO-C4X-222634)
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