[2-(Difluoromethoxy)-5-methylphenyl]boronic acid CAS 958451-75-7
| CAS No. | 958451-75-7 |
| Molecular Formula | C8H9BF2O3 |
| Molecular Weight | 201.96 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of [2-(Difluoromethoxy)-5-methylphenyl]boronic acid is closely related to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
[2-(Difluoromethoxy)-5-methylphenyl]boronic acid (CAS 958451-75-7), molecular formula C8H9BF2O3 and molecular weight 201.96 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of [2-(Difluoromethoxy)-5-methylphenyl]boronic acid (C8H9BF2O3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
CATO manufactures [2-(Difluoromethoxy)-5-methylphenyl]boronic acid under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C8H9BF2O3 |
| Molecular Weight | 201.96 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.5 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
Related Difluoromethoxy Standards
- (4-(Difluoromethoxy)-2-methylphenyl)boronic acid (CAS 514206-39-4)
- (4-(Difluoromethoxy)-3-methylphenyl)boronic acid (CAS 958451-72-4)
- [2-(Difluoromethoxy)-3-methylphenyl]boronic acid (CAS 958451-78-0)
- 3-(Difluoromethoxy)-4-methylphenylboronic acid (CAS 958451-74-6)
- 2-(Difluoromethoxy)-4-methoxybenzaldehyde (CAS 1247613-99-5)
- 3-(difluoromethoxy)-4-methylbenZoic acid (CAS 1249751-97-0)
- 4-(Difluoromethoxy)-3-methylbenzoic acid (CAS 1427373-23-6)
- 3-(Difluoromethoxy)-5-methylbenzoic acid (CAS 1427403-26-6)
Recommended Standards
- 2-(2,2-Difluoroethoxy)phenylboronic Acid (CAS 958452-29-4)
- (5-Ethoxy-2,4-difluorophenyl)boronic acid (CAS 900175-12-4)
- 2,4-Difluoro-3-methoxy-5-methylphenylboronic acid (CAS 2096331-81-4)
- 2,6-Difluoro-3-ethoxyphenylboronic acid (CAS 849062-00-6)
- 2-((4-(4-Chlorophenyl)-5-(4-methoxyphenyl)-4H-1,2,4-triazol-3-yl)thio)-N-(2-isopropylphenyl)acetamide (CAS 476484-51-2)
- 2-Isobutyl-1-oxo-1,4-dihydro-2H-spiro[cyclohexane-1,3-isoquinoline]-4-carboxylic acid (CAS 1225071-45-3)
- 1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine (CAS 23266-24-2)
- (E)-4-(4-(dimethylamino)benzylidene)-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one (CAS 132603-49-7)
- Methyl 5-Chloropyrazolo[1,5-a]pyrimidine-3-carboxylate (CAS 1224944-51-7)
- 1-Ethyl-4-(pyrrolidin-3-yl)piperazine (CAS 1181375-80-3)
- 2-Ethyl-1-(2-methylpiperazin-1-yl)butan-1-one (CAS 1240566-99-7)
- 4,4,5,5-Tetramethyl-2-(3,4,5-trimethoxy-2,6-dimethylphenyl)-1,3,2-dioxaborolane (CAS 2096469-98-4)
- 1-(3-(Trifluoromethyl)phenyl)-1,2-dihydro-3H-pyrazolo[3,4-b]pyridin-3-one (CAS 34580-77-3)
- D-γ-Glu20-Side-Tirzepatide (CAS CATO-CPTD788929)
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