2-(Difluoromethoxy)-3-fluorophenylboronic acid CAS 958451-76-8
| CAS No. | 958451-76-8 |
| Molecular Formula | C7H6BF3O3 |
| Molecular Weight | 205.93 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
2-(Difluoromethoxy)-3-fluorophenylboronic acid (CAS 958451-76-8), molecular formula C7H6BF3O3 and molecular weight 205.93 g/mol, is a CATO reference standard with documented purity and traceability.
2-(Difluoromethoxy)-3-fluorophenylboronic acid (C7H6BF3O3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C7H6BF3O3 |
| Molecular Weight | 205.93 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.5 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
Related Difluoromethoxy Standards
- (4-(Difluoromethoxy)-2-fluorophenyl)boronic acid (CAS 1004775-34-1)
- (2-(Difluoromethoxy)-5-fluorophenyl)boronic acid (CAS 958451-71-3)
- (3-(Difluoromethoxy)-5-fluorophenyl)boronic acid (CAS 2055539-69-8)
- 2-(Difluoromethoxy)-4-fluorophenylboronic acid (CAS 958451-73-5)
- 3-(Difluoromethoxy)-4-fluorophenylboronic acid (CAS 958451-70-2)
- 4-(Difluoromethoxy)-3-fluorophenylboronic Acid (CAS 958451-69-9)
- 2-(Difluoromethoxy)-5-fluorobenzoic acid (CAS 1017779-44-0)
- 4-(Difluoromethoxy)-2-fluorobenzoic acid (CAS 1017779-52-0)
Recommended Standards
- (6-Amino-2-(trifluoromethyl)pyridin-3-yl)boronic acid (CAS 2096338-90-6)
- (4-Hydroxy-2-(trifluoromethyl)phenyl)boronic acid (CAS 943918-05-6)
- 2-Hydroxy-5-(trifluoromethyl)phenylboronic acid (CAS 779329-55-4)
- 2-Hydroxy-6-trifluoromethylphenylboronic acid (CAS 2096333-79-6)
- Clobetasol Propionate Related Compound 1 (CAS 61618-89-1)
- Ethyl 2-(chlorosulfonyl)-6-methylbenzoate (CAS 133742-97-9)
- Aldicarb-oxime (CAS 1646-75-9)
- Baclofen impurity 82 (CAS CATO-C4X-101282)
- 3-(((Benzyloxy)carbonyl)(o-tolyl)amino)propanoic acid (CAS 1340357-73-4)
- m-PEG7-CH2CH2CHO (CAS 1234369-95-9)
- 4-((Benzoyloxy)imino)-5,6-dihydro-4H-thieno[2,3-b]thiopyran 7,7-dioxide (CAS 338963-51-2)
- (6-Chloro-2-oxo-1,3-benzoxazol-3(2H)-yl)acetic acid (CAS 19739-40-3)
- 2-Pyridyl-2,8-bis(trifluoromethyl)-4-quinolyl ketone; [2,8-bis(Trifluoromethyl)-4-quinolyl]-2-pyridyl ketone; 2-Pyridinyl[2,8-bis(trifluoromethyl)-4-quinolinyl]methanone 35853-55-5 AB1006526 (CAS 35853-55-5)
- [D-Ser6]-Semaglutide (CAS CATO-C4X-2226287)
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