Diltiazem Desacetyl O-Desmethyl Hydrochloride CAS 96252-32-3
| CAS No. | 96252-32-3 |
| Molecular Formula | C19H22N2O3S |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Diltiazem Desacetyl O-Desmethyl Hydrochloride is closely related to a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Diltiazem Desacetyl O-Desmethyl Hydrochloride (CAS 96252-32-3), a pharmacopoeial impurity reference standard (molecular formula C19H22N2O3SHCl, MW 394.91 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Diltiazem Desacetyl O-Desmethyl Hydrochloride (C19H22N2O3SHCl) contains a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 9.0, corresponding to approximately 9 ring(s) or double-bond equivalent(s). With a molecular weight of 394.91 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H22N2O3S HCl |
| Molecular Weight | 394.91 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1984 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Diltiazem Standards
- Diltiazem EP Impurity A HCl (CAS 103532-27-0)
- Diltiazem EP Impurity A HCl (CAS 111188-71-7(free base))
- Diltiazem D4 (CAS 112259-41-3)
- Diltiazem USP Related Compound H HCl (CAS 115992-91-1(Free Base))
- Diltiazem EP Impurity H HCl (CAS 115992-91-1(free base))
- Diltiazem Impurity 9 (CAS 116050-35-2)
- Diltiazem Impurity 23 (CAS 119009-50-6)
- Diltiazem-d3 Hydrochloride (CAS 1217623-80-7)
Recommended Standards
- Edaravone Impurity N2 (CAS 168848-20-2)
- Tacrolimus Impurity 4 (CAS 109466-74-2)
- Dabrafenib Impurity 14 (CAS CATO-C4X-303314)
- Ethyl benzo[d]imidazo[2,1-b]thiazole-2-carboxylate (CAS 64951-05-9)
- N-(2,2-Dimethylpropylidene)aniline (CAS 26029-60-7)
- 3-(Pyridin-4-yl)-5-(trifluoromethyl)pyridine-2-thiol (CAS 1214327-01-1)
- 2-((4-Amino-6-methylpyrimidin-2-yl)thio)-N-isopentylacetamide (CAS 1036192-27-4)
- ([1,1′-Biphenyl]-2-olato)dichloro[(1,2,3,4,5-η)-1,2,3,4,5-pentamethyl-2,4-cyclopentadien-1-yl]titanium (CAS 918151-45-8)
- 4-(4-Fluorophenyl)-N-phenyl-1,3-thiazol-2-amine (CAS 1427-09-4)
- Insulin B (22-25) (CAS 34367-73-2)
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