Cefuroxime Sodium EP Impurity E CAS 97232-97-8
| CAS No. | 97232-97-8 |
| Molecular Formula | C16H16N4O8S |
| Molecular Weight | 424.39 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Cefuroxime Sodium EP Impurity E is closely related to a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Cefuroxime Sodium EP Impurity E (CAS 97232-97-8, C16H16N4O8S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Cefuroxime Sodium EP Impurity E (C16H16N4O8S) contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 11.0, corresponding to approximately 11 ring(s) or double-bond equivalent(s). With a molecular weight of 424.39 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Cefuroxime Sodium EP Impurity E meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H16N4O8S |
| Molecular Weight | 424.39 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1984 |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 1 |
Related Cefuroxime Standards
- Cefuroxime Impurity 13 (CAS 229499-08-5)
- Cefuroxime Axetil EP Impurity D (CAS 55268-75-2)
- Cefuroxime Sodium EP Impurity B (CAS 39685-31-9)
- Cefuroxime Sodium EP Impurity G (CAS 97232-98-9)
- Cefuroxime-d3 (CAS 1803240-98-3)
- Cefuroxime impurity 106 (CAS CATO-C4X-1245106)
- Cefuroxime Impurity 48 (CAS CATO-C4X-124548)
- Cefuroxime Impurity 49 (CAS CATO-C4X-124549)
Recommended Standards
- (6R,7S)-Cefuroxime Isomer (CAS CATO-C4X-124519)
- 6-(Dimethylamino)-9-(4-Methylbenzyl)-2-(Trifluoromethyl)-9H-Purine (CAS 117860-34-1)
- N-(3-(benzyloxy)pyridin-2-yl)-4-(trifluoromethoxy)benzenesulfonamide (CAS 497060-26-1)
- N-((2S,3R,4R,5R,6R)-2-(((2R,3S,4R,5R)-5-acetamido-1,2,4-trihydroxy-6-oxohexan-3-yl)oxy)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)acetamide (CAS 136198-41-9)
- Linezolid Impurity 77 (CAS 183905-31-9)
- Carbidopa EP Impurity B (CAS 18181-08-3)
- Olanzapine Impurity 69 (CAS 2485860-97-5)
- 4,4,6-Trimethyl-1,3,2-dioxaborinan-2-ol (CAS 78-60-4)
- (3-Chlorofuran-2-yl)(phenyl)methanol (CAS 944652-59-9)
- Methyl 2-aminononanoate (CAS 181212-92-0)
- 3-(Chloromethyl)quinuclidin-3-ol hydrochloride (CAS 247195-80-8)
- Diethyl 2,3-Bis(benzyloxy) Tartrate (CAS 77312-71-1)
- 3-{1-[2-(3-methoxyphenyl)acetyl]piperidin-4-yl}-4-phenyl-4,5-dihydro-1H-1,2,4-triazol-5-one (CAS 1775519-50-0)
- Des-Gly29,30-Tirzepatide (CAS CATO-CPTD788944)
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