Bosutinib Impurity 25 CAS 98446-49-2
| CAS No. | 98446-49-2 |
| Molecular Formula | C7H7Cl2NO |
| Molecular Weight | 192.04 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 192.04 g/mol gives Bosutinib Impurity 25 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Bosutinib Impurity 25 (CAS 98446-49-2, C7H7Cl2NO) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Bosutinib Impurity 25 (C7H7Cl2NO) contains an amide group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 4.0, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 192.04 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H7Cl2NO |
| Molecular Weight | 192.04 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Bosutinib Standards
- Bosutinib Impurity 12 (CAS 1247618-34-3)
- Bosutinib Impurity 33 (CAS 709-09-1)
- Bosutinib Impurity 7 (CAS 142072-71-7)
- Bosutinib Impurity 27 (CAS CATO-C4X-184727)
- Bosutinib Impurity 1 (CAS 20734-71-8)
- Bosutinib Impurity 26 (CAS 67669-19-6)
- Bosutinib Impurity N1 (CAS 879644-03-8)
- Bosutinib Impurity 6 (CAS 1156068-41-5)
Recommended Standards
- 3,5-Dichloro-4-methoxyaniline (CAS 32407-11-7)
- Clopidol (CAS 2971-90-6)
- Pantoprazole Impurity 28 (CAS 409098-85-7)
- N-(2-Bromoallyl)-N-methylacetamide (CAS 102585-34-2)
- Torasemide Impurity 28 (CAS 58154-83-9)
- Fulvestrant Impurity 8 (CAS 252947-01-6)
- Crisaborole impurity 108 (CAS CATO-C4X-2021108)
- Selenophen-3-ylboronic acid (CAS 35133-85-8)
- 4-Chloro-2-iodopyridin-3-amine (CAS 1805269-67-3)
- 3-Iodo-1-methylpiperidine (CAS 1353944-56-5)
- 4-(Ethylamino)-3-(trifluoromethyl)benzonitrile (CAS 1153007-87-4)
- Tenofovir Impurity 67 (CAS 182626-47-7)
- 1,3,5-Tris(4-nitrophenoxy)benzene (CAS 102852-91-5)
- Insulin Degludec Impurity 14 (CAS CATO-C4X-215714)
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