Nebivolol Impurity 106 CAS 99199-99-2
| CAS No. | 99199-99-2 |
| Molecular Formula | C11H12O2 |
| Molecular Weight | 176.21 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Nebivolol Impurity 106 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Nebivolol Impurity 106 (CAS 99199-99-2, C11H12O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Nebivolol Impurity 106 (C11H12O2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. Its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C11H12O2 |
| Molecular Weight | 176.21 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
Related Nebivolol Standards
- Nebivolol Impurity 90 (CAS 51939-71-0)
- Nebivolol Impurity 5 (CAS 409346-73-2)
- Nebivolol Impurity 50 (CAS 99199-62-9)
- Nebivolol Impurity 42 (CAS 197706-50-6)
- Nebivolol Impurity 43 (CAS 129050-23-3)
- Nebivolol Impurity 44 (CAS 197706-51-7)
- Nebivolol Impurity 45 (CAS 129050-26-6)
- Nebivolol Impurity 74 (CAS CATO-C4X-196874)
Recommended Standards
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- Eperisone Impurity 42 (CAS 40475-69-2)
- Difelikefalin Impurity 86 (CAS CATO-C4X-304186)
- Silodosin Impurity 7 (CAS 350797-56-7)
- Procaine Impurity 18 (CAS CATO-C4X-262318)
- tert-Butyl 4-((1-(pyridin-2-yl)ethyl)amino)piperidine-1-carboxylate (CAS 1289386-20-4)
- 6-Chloro-n,n-bis(propan-2-yl)pyridine-3-sulfonamide (CAS 568566-62-1)
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- 4-Amino-2H-benzo[b][1,4]thiazin-3(4H)-one 1,1-dioxide (CAS 1326915-71-2)
- 3-Chloro-6-fluoropicolinic acid (CAS 1199243-95-2)
- Suvorexant Impurity 37 (CAS CATO-C4X-181237)
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