Nebivolol Impurity 16 CAS 99199-91-4
| CAS No. | 99199-91-4 |
| Molecular Formula | C18H20FNO2 |
| Molecular Weight | 301.36 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO manufactures Nebivolol Impurity 16 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
As a process- or degradation-related impurity, Nebivolol Impurity 16 (CAS 99199-91-4, C18H20FNO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Nebivolol Impurity 16 (C18H20FNO2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C18H20FNO2 |
| Molecular Weight | 301.36 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Nebivolol Standards
- Nebivolol Impurity 56 (CAS CATO-C4X-196856)
- Nebivolol Impurity 14 (CAS 129050-29-9)
- Nebivolol Impurity 15 (CAS 1029684-20-5)
- Nebivolol Impurity 67 (CAS CATO-C4X-196867)
- Nebivolol Impurity 70 (CAS CATO-C4X-196870)
- Nebivolol Impurity 75 (CAS CATO-C4X-196875)
- Nebivolol Impurity 54 (CAS CATO-C4X-196854)
- Nebivolol Impurity 55 (CAS CATO-C4X-196855)
Recommended Standards
- Diltiazem EP Impurity E (CAS 42399-49-5)
- Diltiazem Impurity 21 (CAS 42399-51-9)
- Sotalol impurity 6 (CAS 134720-07-3)
- Diltiazem Impurity 20 (CAS 132830-16-1)
- Emtricitabine impurity 50 (CAS CATO-C4X-123250)
- Resmetirom Impurity 29 (CAS CATO-C4X-291229)
- Irbesartan Impurity 17 (CAS CATO-C4X-166617)
- O-(3-methoxyphenyl)hydroxylamine (CAS 89232-58-6)
- 3-Hydroxy-2-methoxybenzeneboronic acid pinacol ester (CAS 2121514-31-4)
- UR-144 5-Pentanoic acid metabolite (CAS 1451369-33-7)
- 1-Chloro-7-iodoisoquinoline (CAS 1170704-54-7)
- ((2-Chloroacetamido)methyl)triphenylphosphonium chloride (CAS 142414-39-9)
- Linezolid R-Isomer (CAS 872992-20-6)
- Biotinyl-Pancreatic Polypeptide (human) trifluoroacetate salt (CAS 1816258-36-2)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com