5-Chloro-4-fluoro-2-methylpyrimidine CAS 99429-15-9
| CAS No. | 99429-15-9 |
| Molecular Formula | C5H4ClFN2 |
| Molecular Weight | 146.55 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 5-Chloro-4-fluoro-2-methylpyrimidine (C5H4ClFN2) is characterized by a nitrile group, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
5-Chloro-4-fluoro-2-methylpyrimidine (CAS 99429-15-9) is a high-purity analytical reference standard with the molecular formula C5H4ClFN2 and a molecular weight of 146.55 g/mol.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 5-Chloro-4-fluoro-2-methylpyrimidine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C5H4ClFN2 |
| Molecular Weight | 146.55 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
- 5-Chloro-2-fluoropyridin-3-amine (CAS 103999-78-6)
- 4-Chloro-6-(fluoromethyl)pyrimidine (CAS 1092289-36-5)
- 5-Chloro-2-fluoropyridin-4-amine (CAS 1227513-74-7)
- 3-Chloro-2-fluoropyridin-4-amine (CAS 1227577-11-8)
- 3-Chloro-5-fluoropyridin-4-amine (CAS 1227581-38-5)
- 6-Chloro-2-fluoropyridin-3-amine (CAS 1227600-05-6)
- 3-chloro-6-fluoropyridin-2-amine (CAS 1232431-23-0)
- 5-Chloro-6-fluoropyridin-3-amine (CAS 1256790-26-7)
Recommended Standards
- 5-Chloro-2-fluoro-4-methylpyrimidine (CAS 99429-16-0)
- Voriconazole Impurity 24 (CAS 898044-55-8)
- 4-Chloro-5-fluoro-2-methylpyrimidine (CAS 898044-50-3)
- 2-(4-Chloro-1h-pyrazol-1-yl)ethan-1-ol (CAS 1003992-83-3)
- 6-((3-Iodopyridin-2-yl)oxy)furo[3,2-b]pyridine (CAS 1228665-68-6)
- 2-(4-Bromophenyl)-2-(hydroxymethyl)propane-1,3-diol (CAS 936494-74-5)
- 2-chloro-1-[1-(propan-2-yl)-1H-imidazol-2-yl]ethan-1-one (CAS 1379191-35-1)
- N-(4-Methylbenzyl)pyrimidin-2-amine (CAS 111098-42-1)
- Benzyl (2-oxopyrrolidin-3-yl)carbamate (CAS 42259-95-0)
- Benzyl 2-Acetamido-2-deoxy-4,6-O-(4'-methoxybenzylidene)-3-O-(2',3',4',6'-tetra- O-acetyl-β-D-galactopyranosyl)-α-D-galactopyranoside (CAS 121785-18-0)
- 5-(Methoxycarbonyl)pyridine-2-acetic Acid (CAS 1000524-56-0)
- 2-Fluoro-3-formylisonicotinic acid (CAS 1289160-52-6)
- Benzyl 4-[2-(3-piperidinyl)ethoxy]benzoatehydrochloride (CAS 1220016-50-1)
- Tau Peptide (273-284) trifluoroacetate salt (CAS 1663490-91-2)
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