4-Chloro-5-fluoro-2-methylpyrimidine CAS 898044-50-3
| CAS No. | 898044-50-3 |
| Molecular Formula | C5H4ClFN2 |
| Molecular Weight | 146.55 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 146.55 g/mol gives 4-Chloro-5-fluoro-2-methylpyrimidine distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
4-Chloro-5-fluoro-2-methylpyrimidine (CAS 898044-50-3), molecular formula C5H4ClFN2 and molecular weight 146.55 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 4-Chloro-5-fluoro-2-methylpyrimidine (C5H4ClFN2) is characterized by a nitrile group, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4-Chloro-5-fluoro-2-methylpyrimidine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C5H4ClFN2 |
| Molecular Weight | 146.55 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
- 5-Chloro-2-fluoropyridin-3-amine (CAS 103999-78-6)
- 4-Chloro-6-(fluoromethyl)pyrimidine (CAS 1092289-36-5)
- 5-Chloro-2-fluoropyridin-4-amine (CAS 1227513-74-7)
- 3-Chloro-2-fluoropyridin-4-amine (CAS 1227577-11-8)
- 3-Chloro-5-fluoropyridin-4-amine (CAS 1227581-38-5)
- 6-Chloro-2-fluoropyridin-3-amine (CAS 1227600-05-6)
- 3-chloro-6-fluoropyridin-2-amine (CAS 1232431-23-0)
- 5-Chloro-6-fluoropyridin-3-amine (CAS 1256790-26-7)
Recommended Standards
- 4-Chloro-2-fluorophenol (CAS 348-62-9)
- 5-Chloro-2-fluoro-4-methylpyrimidine (CAS 99429-16-0)
- 4-Amino-2-chloro-5-fluoropyridine (CAS 89510-90-7)
- 5-Chloro-4-fluoro-2-methylpyrimidine (CAS 99429-15-9)
- 2-Bromo-5-fluoro-1,1a,6,6a-tetrahydrocyclopropa[a]indene-1-carboxylic acid (CAS 2060050-06-6)
- N-(4-Bromo-5-cyclopropoxypyridin-3-yl)methanesulfonamide (CAS 1243409-83-7)
- (4-Methylpiperazin-1-yl)(piperidin-2-yl)methanone (CAS 1008091-05-1)
- 4-Hydroxy-4-methylhexanoic acid (CAS 93152-28-4)
- 1-(thiophen-3-yl)-2-azaspiro[3.3]heptane hydrochloride (CAS 1955519-96-6)
- 4-Methoxy-1-methylpyrrolidine-2-carboxylic acid (CAS 666849-95-2)
- 2-methyl-2,5-diazabicyclo[4.2.0]octane;dihydrochloride (CAS 2306263-54-5)
- (R)-1-Methylpiperidin-3-ol (CAS 28808-26-6)
- 2-((4-Bromophenyl)amino)-N-(1-methoxypropan-2-yl)acetamide (CAS 1240964-62-8)
- (Tyr?)-C-Type Natriuretic Peptide (32-53) (human, porcine, rat) (CAS 142878-79-3)
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