Indometacin Impurity 51 CAS CATO-C4X-147051
| CAS No. | CATO-C4X-147051 |
| Molecular Formula | C14H12Cl2N2O2 |
| Molecular Weight | 311.16 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Indometacin Impurity 51.
CATO supplies Indometacin Impurity 51 (CAS CATO-C4X-147051), a pharmacopoeial impurity reference standard (molecular formula C14H12Cl2N2O2, MW 311.16 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Indometacin Impurity 51 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 311.16 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H12Cl2N2O2 |
| Molecular Weight | 311.16 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Indometacin Standards
- Indometacin Impurity 50 (CAS CATO-C4X-147050)
- Indometacin Impurity 24 (CAS 99508-25-5)
- Indometacin Impurity 29 (CAS CATO-C4X-147029)
- Indometacin Impurity 59 (CAS CATO-C4X-147059)
- Indometacin Impurity 18 (CAS 75511-23-8)
- Indometacin Impurity 48 (CAS CATO-C4X-147048)
- Indometacin Impurity 49 (CAS CATO-C4X-147049)
- Indometacin Impurity 52 (CAS CATO-C4X-147052)
Recommended Standards
- Roxadustat Impurity 165 (CAS CATO-C4X-2213165)
- Amlodipine Impurity 114 (CAS CATO-C4X-1095114)
- Bosutinib 4-Chloro 7-Chloropropoxy Impurity (CAS 214470-68-5)
- tert-butyl 3-iodopiperidine-1-carboxylate (CAS 850761-36-3)
- Nicorandil Impurity 5 (CAS 1157-74-0)
- Oxandrolone Impurity 1 (CAS 19587-10-1)
- Perphenazine EP Impurity A (CAS 10078-25-8)
- 5-(O-tolylamino)thiazole-4-carboxylic acid (CAS 1342850-07-0)
- 7-Methyl-5-nitroquinolin-8-ol (CAS 1951444-64-6)
- Ethyl 4-(3-(2-benzamidothiazol-4-yl)propanamido)piperidine-1-carboxylate (CAS 1021256-78-9)
- 4-Methoxy-3-(phenylsulfonyl)isobenzofuran-1(3H)-one (CAS 74724-81-5)
- 2,4-Dibromo-5-methoxyaniline (CAS 35736-52-8)
- Ethyl 2-(6-(3-methoxyphenyl)-3-methyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetate (CAS 1011392-42-9)
- Semaglutide impurity 244(Fmoc-His(Fmoc)-Aib-OH) (CAS CATO-C4X-2226244)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com