Vancomycin EP Impurity K CAS 99759-13-4
| CAS No. | 99759-13-4 |
| Molecular Formula | C67H77Cl2N9O24 |
| Molecular Weight | 1463.28 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Vancomycin EP Impurity K (C67H77Cl2N9O24) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
CATO supplies Vancomycin EP Impurity K (CAS 99759-13-4), a pharmacopoeial impurity reference standard (molecular formula C67H77Cl2N9O24, MW 1463.28 g/mol) used for the identification and quantification of trace impurities in APIs.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Vancomycin EP Impurity K meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C67H77Cl2N9O24 |
| Molecular Weight | 1463.28 g/mol |
| Purity | >90% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 33.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 9 |
Related Vancomycin Standards
- Vancomycin impurity 17 (CAS 250273-66-6)
- Vancomycin EP Impurity F (CAS 2415254-43-0)
- Vancomycin EP Impurity L (CAS 79517-31-0)
- Vancomycin EP Impurity B (CAS 555598-85-1)
- Vancomycin EP Impurity E (CAS 55598-85-1)
- Vancomycin EP Impurity I (CAS CATO-C4X-177510)
- Vancomycin EP Impurity J (CAS 2416251-24-4)
- Vancomycin Impurity M (CAS CATO-C4X-177522)
Recommended Standards
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- Ethyl 3-(4-bromobenzoyl)-5-(pyridin-2-yl)indolizine-1-carboxylate (CAS 252201-20-0)
- 2-Bromo-N-(3-(2-oxopyrrolidin-1-yl)phenyl)benzamide (CAS 362601-63-6)
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Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com