Afatinib Impurity 77 CAS CATO-C4X-100677
| CAS No. | CATO-C4X-100677 |
| Molecular Formula | C24H25ClFN5O4 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Afatinib Impurity 77.
As a process- or degradation-related impurity, Afatinib Impurity 77 (CAS CATO-C4X-100677, C24H25ClFN5O4C4H4O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Afatinib Impurity 77 (C24H25ClFN5O4C4H4O4) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 16.0, corresponding to approximately 16 ring(s) or double-bond equivalent(s). With a molecular weight of 618.01 g/mol, it falls into the high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Afatinib Impurity 77 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C24H25ClFN5O4 2*C4H4O4 |
| Molecular Weight | 618.01 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 5 |
Related Afatinib Standards
Recommended Standards
- Avanafil Impurity 5 (CAS 372117-54-9)
- Bimatoprost Impurity 25 (CAS 146964-27-4)
- Apremilast Impurity 35 (CAS CATO-C4X-100935)
- N-(4-((3,4-Dihydroisoquinolin-2(1H)-yl)sulfonyl)phenyl)acetamide (CAS 303132-80-1)
- (3-Methoxyphenyl)(3-methylpyridin-2-yl)methanone (CAS 1187164-04-0)
- N-[3,5-Bis(trifluoromethyl)phenyl]-3-(2-chlorophenyl)-5-methyl-1,2-oxazole-4-carboxamide (CAS 1020252-04-3)
- 1,2,3,4-Tetrahydrobenzo[h]quinoline-3,7-diol (CAS 5855-89-0)
- Rasagiline Impurity 42 (CAS 92249-77-9)
- 3-Methoxy-8-methyl-2-phenylimidazo[1,2-a]pyridine (CAS 89193-00-0)
- Semaglutide impurity 68 (CAS CATO-C4X-222668)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com