Afatinib Impurity 36 CAS CATO-C4X-100636
| CAS No. | CATO-C4X-100636 |
| Molecular Formula | C24H27ClFN5O3 |
| Molecular Weight | 487.95 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 487.95 g/mol gives Afatinib Impurity 36 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Afatinib Impurity 36 (CAS CATO-C4X-100636, C24H27ClFN5O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, Afatinib Impurity 36 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 487.95 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Afatinib Impurity 36 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C24H27ClFN5O3 |
| Molecular Weight | 487.95 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 5 |
Related Afatinib Standards
Recommended Standards
- N-(5-Chloro-2-(3-(9-(4-fluorobenzyl)-3-oxa-7,9-diazabicyclo[3.3.1]nonan-7-yl)-3-oxoprop-1-en-1-yl)-4-methoxyphenyl)acetamide (CAS 921208-19-7)
- Dacomitinib Impurity 48 (CAS CATO-C4X-208648)
- Neratinib Impurity N2 (CAS 915941-95-6)
- Avanafil-13C-d3 (CAS CATO-C4X-111836)
- Semaglutide Impurity 12 (CAS CATO-C4X-222612)
- Fluzoparib Impurity 4 (CAS CATO-C4X-32524)
- Mivacurium chloride Impurity 64 (CAS CATO-C4X-137564)
- 4-[(Z)-2-(2,4-Dichlorophenyl)ethenyl]-2-(3-fluoro-4-iodophenyl)pyrimidine (CAS 477870-85-2)
- 2-Oxo-2-phenylethanethioamide (CAS 4602-31-7)
- 6-Bromo-2-propylquinolin-4-ol (CAS 658079-03-9)
- N-(2,4-dimethylphenyl)-2-((5-phenyl-1,3,4-oxadiazol-2-yl)thio)acetamide (CAS 332101-17-4)
- Ethyl N-(5-amino-3-iodopyridin-2-yl)-N-(ethoxycarbonyl)carbamate (CAS 1971131-37-9)
- 4-(2-(4-(4-Hydroxyphenyl)-4-methylcyclohexyl)propan-2-yl)phenol (CAS 1965-08-8)
- Anti-TF Antigen Peptide P30-1 trifluoroacetate salt (CAS 573664-50-3)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com