Aripiprazole Impurity 88 CAS CATO-C4X-100888
| CAS No. | CATO-C4X-100888 |
| Molecular Formula | C22H24Cl4N6O2 |
| Molecular Weight | 546.28 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Aripiprazole Impurity 88 is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Aripiprazole Impurity 88 (CAS CATO-C4X-100888, C22H24Cl4N6O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C22H24Cl4N6O2, Aripiprazole Impurity 88 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 546.28 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H24Cl4N6O2 |
| Molecular Weight | 546.28 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 6 |
Related Aripiprazole Standards
- Aripiprazole Impurity 18 (CAS 2250242-47-6)
- Aripiprazole Impurity 89 (CAS CATO-C4X-100889)
- Aripiprazole Impurity N2 (CAS 2220149-92-6)
- Aripiprazole Impurity 31 (CAS 2748381-51-1)
- Aripiprazole Impurity 78 (CAS CATO-C4X-100878)
- Aripiprazole-d8 N,N-Dioxide (CAS 1346603-98-2)
- Aripiprazole Impurity 45 (CAS CATO-C4X-100845)
- Aripiprazole N,N-Dioxide (CAS 573691-13-1)
Recommended Standards
- 2-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(2-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)thio)-1-methyl-1H-imidazol-5-yl)hydrazine-1-carboxamide (CAS 303151-92-0)
- 1-3-4-6-Tetra-O-acetyl-2-deoxy-2-(4-5-dichlorophthalimido)-D-glucopyranose (CAS 308796-43-2)
- N,N'-(1,4-phenylene)bis(4-bromobenzenesulfonamide) (CAS 2654-78-6)
- Glucose Impurity 35 (CAS CATO-C4X-209535)
- Albendazole EP Impurity L (CAS 108579-67-5)
- Semaglutide impurity 78 (CAS CATO-C4X-222678)
- Fluocortolone Pivalate EP Impurity D (CAS CATO-C4X-223014)
- 2-Fluoro-4-(furan-3-yl)benzoic acid (CAS 1339862-17-7)
- 2-(4-Methoxybenzyl)-N-(4-methoxyphenyl)thiazole-4-carboxamide (CAS 478030-23-8)
- 2-(2,5-Dichlorophenyl)imidazo[1,2-a]pyridine-3-carboxylic acid (CAS 1426521-22-3)
- 3-Bromo-2-methoxybiphenyl (CAS 337535-26-9)
- 3-[3-[[2-Chloro-3-(trifluoromethyl)benzyl](2,2-diphenylethyl)amino]propoxy]phenylacetic Acid Hydrochloride (CAS 405911-17-3)
- 1-Cyclopentyl-4,5,6,7-tetrahydro-1H-indazol-4-amine (CAS 1484115-68-5)
- a2,3-Sialylglycopeptide (CAS 189035-43-6)
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