Vonoprazan Impurity 185 CAS CATO-C4X-1020185
| CAS No. | CATO-C4X-1020185 |
| Molecular Formula | C21H18FN3O5S |
| Molecular Weight | 443.45 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Vonoprazan Impurity 185.
CATO supplies Vonoprazan Impurity 185 (CAS CATO-C4X-1020185), a pharmacopoeial impurity reference standard (molecular formula C21H18FN3O5S, MW 443.45 g/mol) used for the identification and quantification of trace impurities in APIs.
Vonoprazan Impurity 185 (C21H18FN3O5S) contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H18FN3O5S |
| Molecular Weight | 443.45 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Vonoprazan Standards
- Vonoprazan Fumarate Impurity 122 (CAS CATO-C4X-1020122)
- Vonoprazan Impurity 174 (CAS CATO-C4X-1020174)
- Vonoprazan Impurity 238 (CAS 1831110-76-9)
- Vonoprazan Impurity 145 (CAS CATO-C4X-1020145)
- Vonoprazan Impurity 253 (CAS CATO-C4X-1020253)
- Vonoprazan Impurity 66 (CAS 2170020-79-6)
- Vonoprazan Impurity 296 (CAS CATO-C4X-1020296)
- Vonoprazan Impurity 162 (CAS CATO-C4X-1020162)
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Why CATO?
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- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com