Vonoprazan Impurity 196 CAS CATO-C4X-1020196
| CAS No. | CATO-C4X-1020196 |
| Molecular Formula | C11H8FNO2 |
| Molecular Weight | 205.19 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Vonoprazan Impurity 196 (CAS CATO-C4X-1020196, C11H8FNO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Vonoprazan Impurity 196 (C11H8FNO2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), Vonoprazan Impurity 196 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H8FNO2 |
| Molecular Weight | 205.19 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Vonoprazan Standards
- Vonoprazan Fumarate Impurity 17 (CAS 1883595-38-7)
- Vonoprazan Impurity 244 (CAS CATO-C4X-1020244)
- Vonoprazan Impurity 65 (CAS 1610043-62-3)
- Vonoprazan Impurity 113 (CAS 1956309-28-6)
- Vonoprazan Impurity 173 (CAS CATO-C4X-1020173)
- Vonoprazan Impurity 142 (CAS CATO-C4X-1020142)
- Vonoprazan Impurity 217 (CAS 16420-39-6)
- Vonoprazan Impurity 307 (CAS CATO-C4X-1020307)
Recommended Standards
- Fluconazole Impurity 50 (CAS 58905-21-8)
- 3',4'-Difluoro-[1,1'-biphenyl]-4-amine (CAS 1184136-90-0)
- 6-Fluoro-2-methyl-quinoline-4-carboxylic acid 6-fluoro-2-methyl-4-quinolinecarboxylic acid 6-fluoro-2-methylquinoline-4-carboxylic acid 716-03-0 (CAS 716-03-0)
- 2-(Difluoro-phenyl-methyl)-pyridine (CAS 1204295-90-8)
- Pitavastatin Impurity 57 (CAS CATO-C4X-103757)
- Tinidazole Impurity 22 (CAS CATO-C4X-193022)
- CAS 1642185-28-1 (CAS 1642185-28-1)
- 6-Bromo-2-thioxo-2,3-dihydroquinazolin-4(1H)-one (CAS 49681-96-1)
- methyl thieno[3,2-b]pyridine-6-carboxylate (CAS 212571-01-2)
- 2-Methoxy-4-piperidinomethyl benzophenone (CAS 898770-99-5)
- Triaqua[μ-[1,3,5-benzenetricarboxylato(3-)-κO1:κO′1]][μ3-[1,3,5-benzenetricarboxylato(3-)-κO1:κO3:κO′1]]tricopper (CAS 222404-02-6)
- Mycophenolate Mofetil EP Impurity A (CAS 1322681-36-6)
- Thalidomide 4'-ether-alkylC2-amine (hydrochloride) (CAS 2341840-99-9)
- Tirzepatide Impurity 45 (CAS CATO-C4X-324045)
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