Fluconazole Impurity 50 CAS 58905-21-8
| CAS No. | 58905-21-8 |
| Molecular Formula | C10H8FN3O |
| Molecular Weight | 205.19 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Fluconazole Impurity 50 (CAS 58905-21-8, C10H8FN3O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Fluconazole Impurity 50 (C10H8FN3O) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H8FN3O |
| Molecular Weight | 205.19 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1973 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Fluconazole Standards
- Fluconazole Impurity 7 (CAS 173837-65-5)
- Fluconazole EP Impurity C (CAS 514222-44-7)
- Fluconazole Impurity 69 (CAS 98414-56-3)
- Fluconazole Impurity 11 (CAS 51336-94-8)
- Fluconazole Impurity 6 (CAS 51336-95-9)
- Fluconazole Impurity 12 (CAS 188416-33-3)
- Fluconazole EP Impurity E (CAS 86404-63-9)
- Fluconazole Impurity 41 (CAS CATO-C4X-101941)
Recommended Standards
- 6-Fluoro-2-methyl-quinoline-4-carboxylic acid 6-fluoro-2-methyl-4-quinolinecarboxylic acid 6-fluoro-2-methylquinoline-4-carboxylic acid 716-03-0 (CAS 716-03-0)
- Vonoprazan Fumarate Impurity 17 (CAS 1883595-38-7)
- 3990AE 461026-47-1 6-Fluoro-2-methyl-quinoline-3-carboxylic acid C11H8FNO2 (CAS 461026-47-1)
- Vonoprazan Impurity 196 (CAS CATO-C4X-1020196)
- Olaparib Impurity 32 (CAS CATO-C4X-113532)
- N-Nitroso Fentanyl EP Impurity D (CAS 1184873-14-0)
- Dasatinib Impurity 26 (CAS CATO-C4X-204526)
- 5-Bromo-N-(2-(4-phenylpiperazin-1-yl)ethyl)furan-2-carboxamide (CAS 1049342-22-4)
- 4-Amino-3,5-dimethylbenzenesulfonic Acid (CAS 20804-27-7)
- 7-Fluoro-1-methyl-1,2,3,4-tetrahydroisoquinoline (CAS 249624-75-7)
- 1-(3-Hydroxyphenyl)cyclobutane-1-carboxylic acid (CAS 1307837-71-3)
- Ethyl 2-(4-(hydroxymethyl)phenyl)oxazole-5-carboxylate (CAS 1365969-51-2)
- 9-Phenanthreneboronic Acid (CAS 68572-87-2)
- Tau Peptide (337-368) (Repeat 4 Domain) trifluoroacetate salt (CAS 330456-27-4)
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