Capecitabine Impurity 19 CAS CATO-C4X-102419
| CAS No. | CATO-C4X-102419 |
| Molecular Formula | C9H8FN3O5 |
| Molecular Weight | 257.18 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Capecitabine Impurity 19 (C9H8FN3O5) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
CATO supplies Capecitabine Impurity 19 (CAS CATO-C4X-102419), a pharmacopoeial impurity reference standard (molecular formula C9H8FN3O5, MW 257.18 g/mol) used for the identification and quantification of trace impurities in APIs.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H8FN3O5 |
| Molecular Weight | 257.18 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Capecitabine Standards
- Capecitabine Impurity 12 (CAS 62211-93-2)
- Capecitabine Impurity 14 (CAS 76497-54-6)
- Capecitabine Impurity 41 (CAS CATO-C4X-102441)
- Capecitabine Impurity 55 (CAS CATO-C4X-102455)
- Capecitabine EP Impurity B (CAS 3094-09-5)
- Capecitabine EP Impurity A (CAS 66335-38-4)
- Capecitabine Impurity 16 (CAS CATO-C4X-102416)
- Capecitabine Impurity 18 (CAS 71609-08-0)
Recommended Standards
- N-ethyl-3,5-bis(trifluoromethyl)aniline (CAS 49850-16-0)
- [4-(difluoromethyl)-3-methyl-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid (CAS 1018150-76-9)
- N-[2,5-Bis(trifluoromethyl)benzyl]-N-methylamine (CAS 958863-59-7)
- 1-Bromo-4-(tert-butylsulfonyl)butane (CAS 1119801-61-4)
- Epinastine Impurity 48 (CAS CATO-C4X-184048)
- Estradiol Impurity 51 (CAS 165609-57-4)
- Dronedarone Impurity 20 (CAS CATO-C4X-109220)
- Dapagliflozin Impurity 107 (CAS CATO-C4X-1138107)
- 4-Chloro-1-(2,4-difluorophenyl)-1h-pyrazolo[3,4-d]pyrimidine (CAS 852314-02-4)
- N-[(1R,2R)-2-[[[[(1R,2R)-2-(Dimethylamino)cyclohexyl]amino]thioxomethyl]amino]-1,2-diphenylethyl]-3,5-bis(trifluoromethyl)benzenesulfonamide (CAS 1020665-73-9)
- Tedizolid Impurity 31 (CAS 1239662-46-4)
- 2,2,2-Trifluoro-N-[3-(hydroxymethyl)phenyl]acetamide (CAS 324560-66-9)
- tert-Butyl 3-(4-cyclopropyl-2,5-dioxoimidazolidin-4-yl)propanoate (CAS 1957283-10-1)
- Tau Peptide (74-102) (Exon 3/Insert 2 Domain) trifluoroacetate salt (CAS 1322695-34-0)
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