Capecitabine EP Impurity A CAS 66335-38-4
| CAS No. | 66335-38-4 |
| Molecular Formula | C9H12FN3O4 |
| Molecular Weight | 245.21 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Capecitabine EP Impurity A (C9H12FN3O4) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 245.21 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
CATO supplies Capecitabine EP Impurity A (CAS 66335-38-4), a pharmacopoeial impurity reference standard (molecular formula C9H12FN3O4, MW 245.21 g/mol) used for the identification and quantification of trace impurities in APIs.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H12FN3O4 |
| Molecular Weight | 245.21 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1975 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Capecitabine Standards
- Capecitabine Impurity 16 (CAS CATO-C4X-102416)
- Capecitabine Impurity 18 (CAS 71609-08-0)
- Capecitabine EP Impurity B (CAS 3094-09-5)
- Capecitabine Impurity 28 (CAS 862508-03-0)
- Capecitabine Impurity 19 (CAS CATO-C4X-102419)
- Capecitabine Impurity 12 (CAS 62211-93-2)
- Capecitabine Impurity 14 (CAS 76497-54-6)
- Capecitabine Impurity 41 (CAS CATO-C4X-102441)
Recommended Standards
- 4-Amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one (CAS 10212-20-1)
- Cefixime Impurity C68 (CAS 74440-05-4)
- N-(4-cyano-3-methylisoxazol-5-yl)-4-fluorobenzamide (CAS 478033-14-6)
- Pantoprazole Impurity 58 (CAS CATO-C4X-139958)
- Clobetasone Butyrate EP Impurity I (CAS 639817-47-3)
- Sodium Cromoglicate Impurity 13 (CAS 53878-47-0)
- Dabigatran Impurity 48 (CAS 1304574-20-6)
- 29310-88-1 2H-1-BENZOPYRAN-2-ONE, 3-(BROMOACETYL)- 3-(2-BROMOACETYL)-2H-CHROMEN-2-ONE 3-(BROMOACETYL)-2H-CHROMEN-2-ONE 3-(BROMOACETYL)COUMARIN BC003359 RARECHEM AB KA K003 (CAS 29310-88-1)
- 3-Amino-2-(naphthalen-1-yl)propanoic acid (CAS 100393-37-1)
- (R)-5-[2-(Boc-amino)-3-(5’-chloro-2’-fluoro-4-biphenylyl)propyl]-2,2,5-trimethyl-1,3-dioxane-4,6-dione (CAS 1802379-78-7)
- 4-(2-((4-Methoxybenzyl)(methyl)amino)propanamido)benzamide (CAS 1252052-74-6)
- Dimethyl 3-Hydroxyglutarate (CAS 7250-55-7)
- (2Z)-1-(4-hydroxyphenyl)-3-(naphthalen-1-yl)prop-2-en-1-one 385810-16-2 KS-00002768 (CAS 385810-16-2)
- Semaglutide impurity 199 (CAS CATO-C4X-2226199)
Why CATO?
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