Crizotinib impurity 33 CAS CATO-C4X-102533
| CAS No. | CATO-C4X-102533 |
| Molecular Formula | C9H9Cl2FO3S |
| Molecular Weight | 287.14 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Crizotinib impurity 33 (CAS CATO-C4X-102533) is a certified pharmaceutical impurity reference standard with the molecular formula C9H9Cl2FO3S and a molecular weight of 287.14 g/mol.
Crizotinib impurity 33 (C9H9Cl2FO3S) contains a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H9Cl2FO3S |
| Molecular Weight | 287.14 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Sulfur Atoms | 1 |
Related Crizotinib Standards
- Crizotinib impurity 24 (CAS 141699-59-4)
- Crizotinib impurity 15 (CAS 1175708-03-8)
- Crizotinib Impurity 62 (CAS CATO-C4X-102562)
- Crizotinib Impurity 11 (CAS 1448326-32-6)
- Crizotinib Impurity 69 (CAS CATO-C4X-102569)
- Crizotinib Impurity 71 (CAS CATO-C4X-102571)
- Crizotinib impurity 18 (CAS 2322921-92-4)
- Crizotinib Impurity 46 (CAS CATO-C4X-102546)
Recommended Standards
- 0769AE 2-Chloro-6-[(4-chlorophenyl)(cyano)methyl]-benzenecarbonitrile 338953-31-4 C15H8Cl2N2 (CAS 338953-31-4)
- Felodipine Impurity 39 (CAS CATO-C4X-109439)
- Tetryl (CAS 479-45-8)
- Amlodipine impurity 124 (CAS CATO-C4X-1095124)
- Thioctic acid Impurity 19 (CAS 91140-37-3)
- Bupropion Impurity 77 (CAS CATO-C4X-120377)
- Propranolol Impurity 57 (CAS CATO-C4X-151957)
- 4-(1H-Benzoimidazol-2-yl)-1-phenyl-pyrrolidin-2-one (CAS 380561-11-5)
- cis-3-(Methoxymethyl)cyclobutan-1-amine (CAS 1068704-31-3)
- Erlotinib impurity 140 (CAS 2055840-41-8)
- 2-(4-(tert-Butyl)phenyl)-1H-indene-1,3(2H)-dione (CAS 13935-96-1)
- 2-chloro-4-methyl-7-(trifluoromethyl)quinazoline (CAS 1388055-42-2)
- 3-Hydroxy-5-nitropyridine (CAS 186593-26-0)
- (Des-Bromo)-Neuropeptide B (1-23) (human) (CAS 434897-64-0)
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