Amlodipine impurity 124 CAS CATO-C4X-1095124
| CAS No. | CATO-C4X-1095124 |
| Molecular Formula | C13H12Cl2O3 |
| Molecular Weight | 287.14 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Amlodipine impurity 124.
As a process- or degradation-related impurity, Amlodipine impurity 124 (CAS CATO-C4X-1095124, C13H12Cl2O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C13H12Cl2O3, Amlodipine impurity 124 contains a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 287.14 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Amlodipine impurity 124 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H12Cl2O3 |
| Molecular Weight | 287.14 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
Related Amlodipine Standards
- Amlodipine Impurity 134 (CAS CATO-C4X-1095134)
- Amlodipine Impurity 79 (CAS 3516-73-2)
- Amlodipine Impurity N13 (CAS 70677-78-0)
- Amlodipine Impurity N2 (CAS 111429-90-4)
- Amlodipine Impurity 114 (CAS CATO-C4X-1095114)
- Amlodipine Impurity 77 (CAS 265136-65-0)
- Amlodipine Impurity 27 (CAS 88150-75-8)
- Amlodipine Impurity 156 (CAS CATO-C4X-1095156)
Recommended Standards
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- Ixazomib Impurity 86 (CAS CATO-C4X-126786)
- Olodaterol impurity 36 (CAS CATO-C4X-194336)
- Hydrocortisone EP Impurity M (CAS 566-35-8)
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