Regorafenib Impurity 34 CAS CATO-C4X-104734
| CAS No. | CATO-C4X-104734 |
| Molecular Formula | C13H10FN3O4 |
| Molecular Weight | 291.23 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 291.23 g/mol gives Regorafenib Impurity 34 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Regorafenib Impurity 34 (CAS CATO-C4X-104734) is a certified pharmaceutical impurity reference standard with the molecular formula C13H10FN3O4 and a molecular weight of 291.23 g/mol.
Regorafenib Impurity 34 (C13H10FN3O4) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Regorafenib Impurity 34 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H10FN3O4 |
| Molecular Weight | 291.23 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Regorafenib Standards
- Regorafenib Impurity 33 (CAS CATO-C4X-104733)
- Regorafenib Impurity 22 (CAS CATO-C4X-104722)
- Regorafenib Impurity 80 (CAS CATO-C4X-104780)
- Regorafenib EP Impurity B (CAS 2141961-84-2)
- Regorafenib EP Impurity B (CAS CATO-C4X-10478)
- Regorafenib Impurity 71 (CAS CATO-C4X-104771)
- Regorafenib Impurity 21 (CAS 35592-96-2)
- Regorafenib Impurity 63 (CAS CATO-C4X-104763)
Recommended Standards
- Bumetanide Impurity 42 (CAS 320417-11-6)
- Ths-044 (CAS 62054-67-5)
- 4-(Pentafluorosulfur)-DL-phenylalanine (CAS 1266124-33-7)
- Ethyl 7-hydroxy-2-methyl-7-(trifluoromethyl)-4h,7h-pyrazolo[1,5-a]pyrimidine-6-carboxylate (CAS 923232-09-1)
- Drotaverin Impurity N1 (CAS 56046-20-9)
- Revefenacin impurity 33 (CAS CATO-C4X-203133)
- Brexpiprazole Impurity 165 (CAS CATO-C4X-1131165)
- Bortezomib Impurity 11 (CAS CATO-C4X-107211)
- 8-Bromo-6-chloro-3-fluoroimidazo[1,2-b]pyridazine (CAS 933035-36-0)
- Lanthanum(III) acetate (CAS 917-70-4)
- Ethyl 5-acetoxy-1H-indole-2-carboxylate (CAS 31720-89-5)
- 4-Cyano-1-methyl-1H-pyrazole-5-sulfonamide (CAS 111493-51-7)
- 6-(Trifluoromethyl)pyridazine-3-carboxylic Acid (CAS 1192155-05-7)
- Semaglutide impurity 270 (CAS CATO-C4X-2226270)
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