Regorafenib Impurity 37 CAS CATO-C4X-104737
| CAS No. | CATO-C4X-104737 |
| Molecular Formula | C18H14FN3O4 |
| Molecular Weight | 355.32 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Regorafenib Impurity 37.
Regorafenib Impurity 37 (CAS CATO-C4X-104737) is a certified pharmaceutical impurity reference standard with the molecular formula C18H14FN3O4 and a molecular weight of 355.32 g/mol.
Regorafenib Impurity 37 (C18H14FN3O4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Regorafenib Impurity 37 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C18H14FN3O4 |
| Molecular Weight | 355.32 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Regorafenib Standards
- Regorafenib Impurity 45 (CAS CATO-C4X-104745)
- Regorafenib Impurity 82 (CAS CATO-C4X-104782)
- Regorafenib Impurity 18 (CAS CATO-C4X-104718)
- Regorafenib Impurity 81 (CAS CATO-C4X-104781)
- Regorafenib Impurity N2 (CAS 1333390-56-9)
- Regorafenib Impurity 19 (CAS 2098799-12-1)
- Regorafenib Impurity 83 (CAS CATO-C4X-104783)
- Regorafenib Impurity 23 (CAS CATO-C4X-104723)
Recommended Standards
- N2-Isobutyryl-2'-Fluoro-2'-deoxyguanosine (CAS 80681-25-0)
- Glutathione Impurity 7 (CAS 3773-07-7)
- N-(4-(Benzofuran-2-yl)thiazol-2-yl)-5-nitrofuran-2-carboxamide (CAS 716365-57-0)
- Cephacetrile Impurity 1 (CAS CATO-C4X-23111)
- Eltrombopag impurity 139 (CAS CATO-C4X-1198139)
- Methylnaltrexone Bromide Impurity 7 (CAS CATO-C4X-15217)
- Dalilesen Impurity 8 (CAS 1505484-72-9)
- 1-(Cyanomethyl)-1H-pyrazole-4-carbonitrile (CAS 1556131-20-4)
- (3-Chloropyridin-4-yl)methanesulfonamide (CAS 1492527-58-8)
- 6-iodo-2-methyl-[1,2,4]triazolo[1,5-a]pyridine (CAS 746668-57-5)
- Pazufloxacin Impurity 19 (CAS CATO-C4X-233219)
- Minoxidil Impurity 29 (CAS CATO-C4X-170029)
- Phenyl n-(4-acetylphenyl)carbamate (CAS 99134-77-7)
- Des-Lys16-Tirzepatide (CAS CATO-CPTD788957)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com