Pazopanib Impurity 1 HCl CAS 2518115-74-5
| CAS No. | 2518115-74-5 |
| Molecular Formula | C21H23N7O2S |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 473.98 g/mol gives Pazopanib Impurity 1 HCl distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Pazopanib Impurity 1 HCl (CAS 2518115-74-5), a pharmacopoeial impurity reference standard (molecular formula C21H23N7O2SHCl, MW 473.98 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Pazopanib Impurity 1 HCl (C21H23N7O2SHCl) contains a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 13.0, corresponding to approximately 13 ring(s) or double-bond equivalent(s). With a molecular weight of 473.98 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Pazopanib Impurity 1 HCl meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H23N7O2S HCl |
| Molecular Weight | 473.98 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2000 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 7 |
| Sulfur Atoms | 1 |
Related Pazopanib Standards
- Pazopanib Impurity 28 (CAS 1072836-76-0)
- Pazopanib Impurity 18 (CAS 121-03-9)
- Pazopanib-d6 (CAS 1219592-01-4)
- Pazopanib Impurity 5 (CAS 1226499-97-3)
- Pazopanib Impurity 6 (CAS 1226499-98-4)
- Pazopanib Impurity 50 (CAS 1226500-00-0)
- Pazopanib Impurity 42 (CAS 1226500-01-1)
- Pazopanib Impurity 37 (CAS 1226500-02-2)
Recommended Standards
- Lifitegrast Impurity 73 (CAS 2641788-18-1)
- Rivastigmine EP Impurity H (CAS 586-37-8)
- Moxifloxacin EP Impurity E HCl (CAS 2252446-71-0)
- 3',4'-Dimethyl-[1,1'-biphenyl]-3-carbaldehyde (CAS 343604-07-9)
- 2-Methyl-2,6-diazaspiro[3.3]heptane hemioxalate (CAS 1527515-02-1)
- Ruxolitinib Impurity 4 (CAS 1236033-03-6)
- 1-(2-((Benzyloxy)carbonyl)-1,2,3,4-tetrahydroisoquinolin-6-yl)-3-(tert-butyl)-1H-pyrazole-5-carboxylic acid (CAS 1020173-41-4)
- 2-Cyclopropoxy-6-ethylbenzonitrile (CAS 1243376-02-4)
- Propyl-(2-trifluoromethoxy-ethyl)-ammonium;chloride (CAS 1301739-45-6)
- [5-31]-Semaglutide (CAS CATO-C4X-2226263)
Why CATO?
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