Bromhexine Impurity 66 CAS CATO-C4X-106066
| CAS No. | CATO-C4X-106066 |
| Molecular Formula | C15H21Br2N2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Bromhexine Impurity 66 (C15H21Br2N2I) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, bromine/iodine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a process- or degradation-related impurity, Bromhexine Impurity 66 (CAS CATO-C4X-106066, C15H21Br2N2I) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Bromhexine Impurity 66 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H21Br2N2 I |
| Molecular Weight | 516.05 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br/I-containing |
| Nitrogen Atoms | 2 |
Related Bromhexine Standards
- Bromhexine Impurity 35 (CAS 100-60-7)
- Bromhexine impurity 59 (CAS 100669-81-6)
- Bromhexine Impurity 51 (CAS 100669-82-7)
- Bromhexine EP Impurity D(2HCl) (CAS 10076-98-9)
- Bromhexine Impurity 22 (CAS 114059-99-3)
- Bromhexine Impurity 17 (CAS 114390-40-8)
- Bromhexine Impurity N3 (CAS 114390-41-9)
- Bromhexine impurity 60 (CAS 1261676-18-9)
Recommended Standards
- Rebamipide Impurity 31 (CAS CATO-C4X-152331)
- Sarecycline Impurity 6 (CAS CATO-C4X-27986)
- Vancomycin EP Impurity I (CAS CATO-C4X-177510)
- Pazopanib Impurity 41 (CAS 2095544-42-4)
- 3-Iodo-4-(trifluoromethyl)aniline (CAS 1261622-18-7)
- Tofacitinib Impurity 66 (CAS 477600-69-4)
- 2-{4-[2-(3-Piperidinyl)ethyl]-1-piperazinyl}-1-ethanol dihydrochloride (CAS 1220038-30-1)
- Ethyl 3-azabicyclo[3.1.0]hexane-1-carboxylate (CAS 63618-09-7)
- N-(5-Oxido-2-phenyl-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)-2-phenylacetamide (CAS 957624-87-2)
- Semaglutide impurity 69 (CAS CATO-C4X-222669)
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