Ibrutinib Impurity 114 CAS CATO-C4X-1064114
| CAS No. | CATO-C4X-1064114 |
| Molecular Formula | C22H21N7O2 |
| Molecular Weight | 415.45 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 415.45 g/mol gives Ibrutinib Impurity 114 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Ibrutinib Impurity 114 (CAS CATO-C4X-1064114) is a certified pharmaceutical impurity reference standard with the molecular formula C22H21N7O2 and a molecular weight of 415.45 g/mol.
Ibrutinib Impurity 114 (C22H21N7O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Ibrutinib Impurity 114 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H21N7O2 |
| Molecular Weight | 415.45 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 7 |
Related Ibrutinib Standards
- Ibrutinib Impurity 97 (CAS 2256059-43-3)
- Ibrutinib Impurity 37 (CAS CATO-C4X-106437)
- Ibrutinib Impurity 62 (CAS CATO-C4X-106462)
- Ibrutinib Impurity 130 (CAS 1633352-71-2)
- Ibrutinib Impurity 196 (CAS CATO-C4X-1064196)
- Ibrutinib Impurity 134 (CAS CATO-C4X-1064134)
- Ibrutinib Impurity 4 (CAS 1288338-95-3)
- Ibrutinib Impurity 136 (CAS 2190506-59-1)
Recommended Standards
- Ethyl (3-methyl-8-((4-sulfamoylbenzyl)amino)pyrido[2,3-b]pyrazin-6-yl)carbamate (CAS 21271-88-5)
- 7-[(4-Ethyl-1-piperazinyl)[4-(trifluoromethyl)phenyl]methyl]-8-quinolinol (CAS 315698-17-0)
- Acalabrutinib Impurity 16 (CAS 2230757-50-1)
- Ponatinib Impurity N72 (CAS 957147-18-1)
- Pyridoxine Impurity 38 (CAS CATO-C4X-187738)
- Risperidone Impurity N1 (CAS 1797131-18-0)
- 5,6-Dehydro-N-methyl Desloratadine (CAS 117811-18-4)
- (2-(((1h-Imidazol-2-yl)methyl)amino)phenyl)methanol (CAS 1251199-48-0)
- 2-(1-Piperazinyl)-4-thiazolecarbonitrile (CAS 1226516-30-8)
- 4-Chloro-1,3-dimethyl-6-phenyl-1H-pyrazolo[3,4-d]pyrimidine (CAS 1956332-56-1)
- 5-(Pyridazin-3-yl)nicotinaldehyde (CAS 1346687-43-1)
- 2-Cyclopropyl-4H,5H,6H,7H-pyrazolo[1,5-a]pyrazine (CAS 1554484-85-3)
- 2-amino-3-(piperidin-1-yl)propan-1-ol dihydrochloride (CAS 1803605-69-7)
- Insulin Degludec Impurity 3 (CAS CATO-C4X-21573)
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