Ponatinib Impurity N72 CAS 957147-18-1
| CAS No. | 957147-18-1 |
| Molecular Formula | C23H24F3N3O |
| Molecular Weight | 415.45 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, Ponatinib Impurity N72 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 415.45 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a process- or degradation-related impurity, Ponatinib Impurity N72 (CAS 957147-18-1, C23H24F3N3O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C23H24F3N3O |
| Molecular Weight | 415.45 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Ponatinib Standards
- Ponatinib Impurity 42 (CAS CATO-C4X-226942)
- Ponatinib Impurity 13 (CAS CATO-C4X-226913)
- Ponatinib Impurity 33 (CAS CATO-C4X-226933)
- Ponatinib Impurity 31 (CAS CATO-C4X-226931)
- Ponatinib Impurity 9 (CAS CATO-C4X-22699)
- Ponatinib Impurity 45 (CAS CATO-C4X-226945)
- Ponatinib Impurity 53 (CAS CATO-C4X-226953)
- Ponatinib Impurity 60 (CAS CATO-C4X-226960)
Recommended Standards
- 1-(1-Hydroxycyclohexyl)propan-2-one (CAS 25290-13-5)
- 7-[(4-Ethyl-1-piperazinyl)[4-(trifluoromethyl)phenyl]methyl]-8-quinolinol (CAS 315698-17-0)
- 4-Bromo-2-(tert-butyl)-7-chloro-6-iodooxazolo[4,5-c]pyridine (CAS 1305324-59-7)
- Ethyl (3-methyl-8-((4-sulfamoylbenzyl)amino)pyrido[2,3-b]pyrazin-6-yl)carbamate (CAS 21271-88-5)
- Cefotaxime Impurity 65 (CAS CATO-C4X-120165)
- Bilastine impurity 114 (CAS CATO-C4X-2253114)
- Labetalol Impurity 68 (CAS CATO-C4X-246668)
- 2-[1-(propan-2-yl)-1h-1,2,3-triazol-4-yl]propan-2-amine (CAS 1344092-78-9)
- N-(3-Chlorophenyl)-2-((5-(4-hydroxyphenyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)acetamide (CAS 332906-59-9)
- 3-(3-Fluorophenyl)-4-methyl-5-(methylsulfonyl)-4H-1,2,4-triazole (CAS 144165-21-9)
- Landiolol Impurity 94 (CAS CATO-C4X-262194)
- Icosanoic anhydride (CAS 55726-22-2)
- 2-{4-[(2,5-dimethoxyphenyl)methyl]piperazin-1-yl}pyridine-4-carbonitrile (CAS 1864064-37-8)
- (Asn5)-Delta-Sleep Inducing Peptide (H-2555.0005) (CAS 80064-67-1)
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