Empagliflozin impurity 184 CAS CATO-C4X-1065184
| CAS No. | CATO-C4X-1065184 |
| Molecular Formula | C13H7FI2O |
| Molecular Weight | 452.00 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Empagliflozin impurity 184.
Empagliflozin impurity 184 (CAS CATO-C4X-1065184) is a certified pharmaceutical impurity reference standard with the molecular formula C13H7FI2O and a molecular weight of 452.00 g/mol.
Empagliflozin impurity 184 (C13H7FI2O) contains a hydroxyl group, an ether linkage, fluorine/iodine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H7FI2O |
| Molecular Weight | 452.00 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/I-containing |
Related Empagliflozin Standards
- Empagliflozin Impurity 79 (CAS 2452301-24-3)
- Empagliflozin Impurity 101 (CAS CATO-C4X-1065101)
- Empagliflozin impurity 02 (CAS 1620758-31-7&1620758-32-8)
- Empagliflozin (CAS 864070-44-0)
- Empagliflozin Impurity 1 (CAS 864070-43-9)
- Empagliflozin Impurity 10 (CAS 2452301-42-5)
- Empagliflozin Impurity 117 (CAS CATO-C4X-1065117)
- Empagliflozin Impurity 118 (CAS CATO-C4X-1065118)
Recommended Standards
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- Ceritinib Impurity 63 (CAS CATO-C4X-104863)
- Pretomanid Impurity 21 (CAS CATO-C4X-260621)
- Montelukast EP Impurity D (CAS 1187586-61-3)
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- 2-(4-fluorophenyl)ethane-1-sulfonamide (CAS 405219-37-6)
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