Empagliflozin impurity 225 CAS CATO-C4X-1065225
| CAS No. | CATO-C4X-1065225 |
| Molecular Formula | C13H7BrClFO |
| Molecular Weight | 313.55 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Empagliflozin impurity 225 is closely related to a hydroxyl group, an ether linkage, fluorine/chlorine/bromine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Empagliflozin impurity 225 (CAS CATO-C4X-1065225) is a certified pharmaceutical impurity reference standard with the molecular formula C13H7BrClFO and a molecular weight of 313.55 g/mol.
Owing to a hydroxyl group, an ether linkage, fluorine/chlorine/bromine substitution, an aromatic ring system, Empagliflozin impurity 225 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 313.55 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H7BrClFO |
| Molecular Weight | 313.55 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl/Br-containing |
Related Empagliflozin Standards
- Empagliflozin Impurity 162 (CAS 1715629-30-3)
- Empagliflozin Impurity 172 (CAS CATO-C4X-1065172)
- Empagliflozin Impurity 282 (CAS 1712958-06-9)
- Empagliflozin Impurity 151 (CAS 915095-85-1)
- Empagliflozin Impurity 147 (CAS 501009-13-8)
- Empagliflozin Impurity 63 (CAS 1360568-68-8)
- Empagliflozin Impurity 130 (CAS 289039-54-9)
- Empagliflozin Impurity 281 (CAS 1096342-71-0)
Recommended Standards
- 951890-40-7 2-Bromo-3'-chloro-5'-fluorobenzophenone MFCD09801477 (CAS 951890-40-7)
- 2-Acetamido-6-bromopyridine-4-sulfonyl chloride (CAS 1393534-01-4)
- Methyl 5-bromo-2-(chlorosulfonyl)benzoate (CAS 736948-72-4)
- 2-Chloro-n-(2-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetamide (CAS 1704121-19-6)
- Bortezomib Impurity 3 (CAS 289472-78-2)
- S-Adenosyl-L-Methionine Impurity 13 (CAS CATO-C4X-138113)
- Baloxavir Marboxil Impurity 229 (CAS CATO-C4X-2108229)
- trans-cyclohexane-1,3-dicarboxylic acid (CAS 2305-30-8)
- 2-(Prop-2-yn-1-yloxy)benzoic acid (CAS 55582-31-5)
- 7-Amino-3-benzyl-4-oxo-1,4-dihydropyrazolo[5,1-c][1,2,4]triazine-8-carbonitrile (CAS 1355202-20-8)
- Spiro[3.5]Nonan-5-one (CAS 7141-75-5)
- 2-(1H-pyrazol-4-yl)-2-azaspiro[4.4]Nonane-1,3-dione (CAS 1155116-28-1)
- 2-(8-Methoxyquinolin-3-yl)acetonitrile (CAS 1421602-00-7)
- SAMS Peptide (CAS 125911-68-4)
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