Empagliflozin impurity 228 CAS CATO-C4X-1065228
| CAS No. | CATO-C4X-1065228 |
| Molecular Formula | C23H27ClO7 |
| Molecular Weight | 450.91 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Empagliflozin impurity 228 is closely related to a flavonoid core, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Empagliflozin impurity 228 (CAS CATO-C4X-1065228, C23H27ClO7) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Empagliflozin impurity 228 (C23H27ClO7) is characterized by a flavonoid core, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Empagliflozin impurity 228 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C23H27ClO7 |
| Molecular Weight | 450.91 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
Related Empagliflozin Standards
- Empagliflozin impurity 02 (CAS 1620758-31-7&1620758-32-8)
- Empagliflozin (CAS 864070-44-0)
- Empagliflozin Impurity 1 (CAS 864070-43-9)
- Empagliflozin Impurity 10 (CAS 2452301-42-5)
- Empagliflozin Impurity 117 (CAS CATO-C4X-1065117)
- Empagliflozin Impurity 118 (CAS CATO-C4X-1065118)
- Empagliflozin Impurity 13 (CAS CATO-C4X-106513)
- Empagliflozin Impurity 131 (CAS CATO-C4X-1065131)
Recommended Standards
- Empagliflozin impurity 203 (CAS CATO-C4X-1065203)
- Empagliflozin impurity 234 (CAS 1417573-74-0)
- Empagliflozin R-Furanoes (CAS 1620758-31-7)
- Empagliflozin Impurity 27 (CAS CATO-C4X-106527)
- Etoricoxib Impurity 11 (CAS 2901801-70-3)
- Furfural Impurity 1 (CAS 7389-38-0)
- Josamycin EP Impurity E (Platenomycin A1) (CAS 40615-47-2)
- 4-chloro-7-methyl-1-benzofuran-3-carboxylic acid (CAS 1483815-00-4)
- 4-Chloro-3-nitrobenzanilide (CAS 41614-16-8)
- Azilsartan Impurity 185 (CAS CATO-C4X-1096185)
- 3-Bromo-5-ethyl-6-methoxy-2-methylpyridine (CAS 867006-25-5)
- 2-Methyl-3-(oxazolo[4,5-b]pyridin-2-yl)aniline (CAS 328907-88-6)
- 7-Bromo-2-(chloromethyl)-5-methoxybenzo[d]oxazole (CAS 1092352-84-5)
- Neuropeptide Y (18-36) (CAS 114495-97-5)
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