Empagliflozin impurity 266 CAS CATO-C4X-1065266
| CAS No. | CATO-C4X-1065266 |
| Molecular Formula | C18H18ClIO2 |
| Molecular Weight | 428.69 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Empagliflozin impurity 266 (CAS CATO-C4X-1065266, C18H18ClIO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Empagliflozin impurity 266 (C18H18ClIO2) contains a steroid core, a hydroxyl group, an ether linkage, chlorine/iodine substitution. The molecule exhibits a degree of unsaturation (DBE) of 9.0, corresponding to approximately 9 ring(s) or double-bond equivalent(s). With a molecular weight of 428.69 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Empagliflozin impurity 266 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H18ClIO2 |
| Molecular Weight | 428.69 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl/I-containing |
Related Empagliflozin Standards
- Empagliflozin impurity 267 (CAS CATO-C4X-1065267)
- Empagliflozin impurity 268 (CAS CATO-C4X-1065268)
- Empagliflozin impurity 269 (CAS CATO-C4X-1065269)
- Empagliflozin Impurity 289 (CAS CATO-C4X-1065289)
- Empagliflozin Impurity 290 (CAS CATO-C4X-1065290)
- Empagliflozin Impurity 291 (CAS CATO-C4X-1065291)
- Empagliflozin Impurity 311 (CAS CATO-C4X-1065311)
- Empagliflozin Impurity 312 (CAS CATO-C4X-1065312)
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