Empagliflozin impurity 268 CAS CATO-C4X-1065268
| CAS No. | CATO-C4X-1065268 |
| Molecular Formula | C18H18ClIO2 |
| Molecular Weight | 428.69 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Empagliflozin impurity 268 (CAS CATO-C4X-1065268, C18H18ClIO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Empagliflozin impurity 268 (C18H18ClIO2) contains a steroid core, a hydroxyl group, an ether linkage, chlorine/iodine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), Empagliflozin impurity 268 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H18ClIO2 |
| Molecular Weight | 428.69 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl/I-containing |
Related Empagliflozin Standards
- Empagliflozin impurity 266 (CAS CATO-C4X-1065266)
- Empagliflozin impurity 267 (CAS CATO-C4X-1065267)
- Empagliflozin impurity 269 (CAS CATO-C4X-1065269)
- Empagliflozin Impurity 289 (CAS CATO-C4X-1065289)
- Empagliflozin Impurity 290 (CAS CATO-C4X-1065290)
- Empagliflozin Impurity 291 (CAS CATO-C4X-1065291)
- Empagliflozin Impurity 311 (CAS CATO-C4X-1065311)
- Empagliflozin Impurity 312 (CAS CATO-C4X-1065312)
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